Norepinephrine Bitartrate Interactions

Brand names: Norepinephrine

Route: Intravenous

Contraindications

4 CONTRAINDICATIONS None. None. ( 4 )

Pregnancy & Breastfeeding

8.1 Pregnancy Risk Summary Limited published data consisting of a small number of case reports and multiple small trials involving the use of norepinephrine in pregnant women at the time of delivery have not identified an increased risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. There are risks to the mother and fetus from hypotension associated with septic shock, myocardial infarction and stroke which are medical emergencies in pregnancy and can be fatal if left untreated (see Clinical Considerations ) . In animal reproduction studies, using high doses of intravenous norepinephrine resulted in lowered maternal placental blood flow. Clinical relevance to changes in the human fetus is unknown since the average maintenance dose is ten times lower (see Data ) . Increased fetal reabsorptions were observed in pregnant hamsters after receiving daily injections at approximately 2 times the maximum recommended dose on a mg/m 2 basis for four days during organogenesis (see Data ) . The estimated background risk for major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively. Clinical Considerations Disease-associated maternal and/or embryo/fetal risk Hypotension associated with septic shock, myocardial infarction, and stroke are medical emergencies in pregnancy which can be fatal if left untreated. Delaying treatment in pregnant women with hypotension associated with septic shock, myocardial infarction and stroke may increase the risk of maternal and fetal morbidity and mortality. Life-sustaining therapy for the pregnant woman should not be withheld due to potential concerns regarding the effects of norepinephrine on the fetus. Data Animal Data A study in pregnant sheep r

15 interactions on record

Norepinephrine Bitartrate + AmitriptylineMajor

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Norepinephrine Bitartrate + ClomipramineMajor

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Norepinephrine Bitartrate + DesipramineMajor

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Norepinephrine Bitartrate + ImipramineMajor

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Norepinephrine Bitartrate + LinezolidMajor

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Norepinephrine Bitartrate + NortriptylineMajor

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Norepinephrine Bitartrate + ProtriptylineMajor

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

Norepinephrine Bitartrate + Insulin HumanModerate

Norepinephrine can decrease insulin sensitivity and raise blood glucose. Monitor glucose and consider dosage adjustment.

Source: NLP:norepinephrine bitartrate