Nortriptyline Interactions

Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot be avoided.

Source: NLP:norepinephrine bitartrate

CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing nortriptyline exposure. Dose reduction may be necessary.

Source: NLP:bupropion hcl er (xl)

CYP2D6-metabolized antidepressant. Bupropion inhibits CYP2D6 and can increase nortriptyline concentrations. Consider dose reduction.

Source: NLP:bupropion hydrochloride

Dosage adjustment of nortriptyline may be necessary when used concomitantly with divalproex sodium delayed-release tablets.

Source: NLP:divalproex sodium

Concomitant use may potentiate the cardiovascular effects of dopamine, including hypertension.

Source: NLP:dopamine hydrochloride

Fluconazole increases the effect of nortriptyline. Dosage adjustment may be necessary; monitor plasma levels.

Source: NLP:fluconazole

Paroxetine is a strong CYP2D6 inhibitor that may increase nortriptyline concentrations. Use caution and monitor.

Source: NLP:paroxetine

Rifampin increases metabolism of nortriptyline, requiring higher than expected doses; discontinuation causes nortriptyline levels to rise.

Source: NLP:rifampin

Dosage adjustment of nortriptyline may be necessary if used concomitantly with valproate due to altered pharmacokinetics.

Source: NLP:valproate sodium

Dosage adjustment may be necessary if used concomitantly with valproic acid.

Source: NLP:valproic acid