Nortriptyline has 13 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Norepinephrine Bitartrate, Bupropion, Bupropion Hcl Er. Patients taking Nortriptyline should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Major
- 1
- Moderate
- 12
Major (1)
- Nortriptyline + Norepinephrine Bitartrate— Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot…
Moderate (12)
- Nortriptyline + Bupropion— CYP2D6 substrate; bupropion inhibits CYP2D6 and increases nortriptyline concentrations; consider dose reduction.
- Nortriptyline + Bupropion Hcl Er— Bupropion inhibits CYP2D6 and can increase nortriptyline concentrations; consider dose reduction of nortriptyline.
- Nortriptyline + Bupropion Hcl Er (Xl)— CYP2D6 substrate antidepressant. Bupropion inhibits CYP2D6, increasing nortriptyline exposure. Dose reduction may be nec…
- Nortriptyline + Bupropion Hydrobromide— CYP2D6 substrate. Bupropion inhibits CYP2D6 and can increase nortriptyline concentrations. Consider dose reduction of no…
- Nortriptyline + Bupropion Hydrochloride— CYP2D6-metabolized antidepressant. Bupropion inhibits CYP2D6 and can increase nortriptyline concentrations. Consider dos…
- Nortriptyline + Divalproex Sodium— Dosage adjustment of nortriptyline may be necessary when used concomitantly with divalproex sodium delayed-release table…
- Nortriptyline + Dopamine Hydrochloride— Concomitant use may potentiate the cardiovascular effects of dopamine, including hypertension.
- Nortriptyline + Fluconazole— Fluconazole increases the effect of nortriptyline. Dosage adjustment may be necessary; monitor plasma levels.
- Nortriptyline + Paroxetine— Paroxetine is a strong CYP2D6 inhibitor that may increase nortriptyline concentrations. Use caution and monitor.
- Nortriptyline + Rifampin— Rifampin increases metabolism of nortriptyline, requiring higher than expected doses; discontinuation causes nortriptyli…
- Nortriptyline + Valproate Sodium— Dosage adjustment of nortriptyline may be necessary if used concomitantly with valproate due to altered pharmacokinetics…
- Nortriptyline + Valproic Acid— Dosage adjustment may be necessary if used concomitantly with valproic acid.