Fosaprepitant Dimeglumine has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Pimozide, Alprazolam, Clarithromycin. Patients taking Fosaprepitant Dimeglumine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 1
- Major
- 13
- Moderate
- 6
Contraindicated (1)
- Fosaprepitant Dimeglumine + Pimozide— Fosaprepitant for injection is contraindicated due to increased pimozide exposure via CYP3A4 inhibition.
Major (13)
- Fosaprepitant Dimeglumine + Alprazolam— Increased alprazolam exposure may increase risk of adverse reactions. Monitor for benzodiazepine-related adverse reactio…
- Fosaprepitant Dimeglumine + Clarithromycin— Intervention Avoid concomitant use of FOCINVEZ Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, i…
- Fosaprepitant Dimeglumine + Ifosfamide— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
- Fosaprepitant Dimeglumine + Itraconazole— Intervention Avoid concomitant use of FOCINVEZ Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, i…
- Fosaprepitant Dimeglumine + Ketoconazole— Intervention Avoid concomitant use of FOCINVEZ Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, i…
- Fosaprepitant Dimeglumine + Midazolam— Increased midazolam exposure may increase risk of adverse reactions. Monitor for benzodiazepine-related adverse reaction…
- Fosaprepitant Dimeglumine + Nelfinavir— Intervention Avoid concomitant use of FOCINVEZ Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, i…
- Fosaprepitant Dimeglumine + Oral Contraceptives— Decreased hormonal exposure during administration and for 28 days after last dose. Effective alternative or back-up cont…
- Fosaprepitant Dimeglumine + Ritonavir— Intervention Avoid concomitant use of FOCINVEZ Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, i…
- Fosaprepitant Dimeglumine + Triazolam— Increased triazolam exposure may increase risk of adverse reactions. Monitor for benzodiazepine-related adverse reaction…
- Fosaprepitant Dimeglumine + Troleandomycin— Intervention Avoid concomitant use of FOCINVEZ Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, i…
- Fosaprepitant Dimeglumine + Vinblastine— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
- Fosaprepitant Dimeglumine + Vincristine— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
Moderate (6)
- Fosaprepitant Dimeglumine + Dexamethasone— Increased dexamethasone exposure. Reduce dose of oral dexamethasone by approximately 50%.
- Fosaprepitant Dimeglumine + Docetaxel— Increased exposure possible via CYP3A4 inhibition, but no dosage adjustment needed. Monitor for adverse reactions.
- Fosaprepitant Dimeglumine + Etoposide— Increased exposure possible via CYP3A4 inhibition, but no dosage adjustment needed. Monitor for adverse reactions.
- Fosaprepitant Dimeglumine + Methylprednisolone— Increased methylprednisolone exposure. Reduce oral dose by 50% on Days 1-2 (HEC) or Day 1 (MEC); reduce IV dose by 25% o…
- Fosaprepitant Dimeglumine + Paclitaxel— Increased exposure possible via CYP3A4 inhibition, but no dosage adjustment needed. Monitor for adverse reactions.
- Fosaprepitant Dimeglumine + Vinorelbine— Increased exposure possible via CYP3A4 inhibition, but no dosage adjustment needed. Monitor for adverse reactions.