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Oxacillin

Also known as: Oxacillin

Route: Intramuscular, Intravenous

4 interactions on record

Oxacillin has 4 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Tetracycline, Probenecid. Patients taking Oxacillin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 4
Major: 1
Moderate: 1

Major (1)

Oxacillin + Tetracycline— Tetracycline may antagonize the bactericidal effect of oxacillin; concurrent use should be avoided.

Moderate (1)

Oxacillin + Probenecid— Probenecid increases and prolongs oxacillin blood levels by blocking renal tubular secretion. Use should be limited to i…

Oxacillin + Tetracycline⚠️Major

Tetracycline may antagonize the bactericidal effect of oxacillin; concurrent use should be avoided.

Oxacillin + Probenecid🟡Moderate

Probenecid increases and prolongs oxacillin blood levels by blocking renal tubular secretion. Use should be limited to infections requiring very high serum levels.

Oxacillin + Oxacillin Sodiumℹ️Unknown

Oxacillin blood levels may be increased and prolonged by concurrent administration of probenecid which blocks the renal tubular secretion of penicillins. Oxacillin-probenecid therapy should be limited to those infections where very high serum levels of oxacillin are necessary.

Oxacillin + Penicillinℹ️Unknown

Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided. Oxacillin blood levels may be increased and prolonged by concurrent administration of probenecid which blocks the renal tubular secretion of penicillins. Probenecid decreases the apparent volume of distribution and slows the rate of excretion by competitively inhibiting renal tubular secretion of penicillins.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.