Oxymorphone has 4 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alprazolam, Alprazolam C-Iv, Midazolam. Patients taking Oxymorphone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 3
- Moderate
- 1
Major (3)
- Oxymorphone + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
- Oxymorphone + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Oxymorphone + Midazolam— Concomitant use increases risk of respiratory depression through actions at different CNS receptor sites.
Moderate (1)
- Oxymorphone + Tapentadol Hydrochloride— Mixed agonist/antagonist and partial agonist opioids may reduce analgesic effect of tapentadol and/or precipitate withdr…