Oxytocin Interactions

Brand names: Pitocin

Oxytocic

Route: Intravenous

FDA Black Box Warning

IMPORTANT NOTICE Elective induction of labor is defined as the initiation of labor in a pregnant individual who has no medical indications for induction. Since the available data are inadequate to evaluate the benefits-to-risks considerations, Pitocin is not indicated for elective induction of labor.

Contraindications

CONTRAINDICATIONS Antepartum use of Pitocin is contraindicated in any of the following circumstances: Where there is significant cephalopelvic disproportion; In unfavorable fetal positions or presentations, such as transverse lies, which are undeliverable without conversion prior to delivery; In obstetrical emergencies where the benefit-to-risk ratio for either the fetus or the mother favors surgical intervention; In fetal distress where delivery is not imminent; Where adequate uterine activity fails to achieve satisfactory progress; Where the uterus is already hyperactive or hypertonic; In cases where vaginal delivery is contraindicated, such as invasive cervical carcinoma, active herpes genitalis, total placenta previa, vasa previa, and cord presentation or prolapse of the cord; In patients with hypersensitivity to the drug.

Pregnancy & Breastfeeding

Pregnancy Teratogenic Effects Animal reproduction studies have not been conducted with oxytocin. There are no known indications for use in the first trimester of pregnancy other than in relation to spontaneous or induced abortion. Based on the wide experience with this drug and its chemical structure and pharmacological properties, it would not be expected to present a risk of fetal abnormalities when used as indicated. Nonteratogenic Effects See ADVERSE REACTIONS in the fetus or neonate.

12 interactions on record

Oxytocin + Carboprost TromethamineContraindicated

Carboprost tromethamine may augment the activity of other oxytocic agents. Concomitant use is not recommended.

Source: NLP:carboprost tromethamine

Oxytocin + DinoprostoneContraindicated

Concomitant intravenous use is contraindicated as dinoprostone may augment the activity of oxytocic agents. Remove vaginal insert at least 30 minutes before administering an oxytocic agent.

Source: NLP:dinoprostone

Oxytocin + MisoprostolContraindicated

Prostaglandins such as misoprostol may augment oxytocic activity, especially when given less than 4 hours prior to oxytocin. Concomitant use is not recommended.

Source: NLP:misoprostol

Oxytocin + CyclopropaneMajor

Cyclopropane anesthesia may modify oxytocin's cardiovascular effects, producing unexpected hypotension and maternal sinus bradycardia with abnormal atrioventricular rhythms.

Source: NLP:oxytocin

Oxytocin + Ephedrine SulfateMajor

Serious postpartum hypertension and stroke reported with concurrent vasopressor and oxytocic use. Carefully monitor blood pressure.

Source: NLP:ephedrine sulfate