Oxytocin has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carboprost Tromethamine, Dinoprostone, Misoprostol. Patients taking Oxytocin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 3
- Major
- 7
- Moderate
- 2
Contraindicated (3)
- Oxytocin + Carboprost Tromethamine— Carboprost tromethamine may augment the activity of other oxytocic agents. Concomitant use is not recommended.
- Oxytocin + Dinoprostone— Concomitant intravenous use is contraindicated as dinoprostone may augment the activity of oxytocic agents. Remove vagin…
- Oxytocin + Misoprostol— Prostaglandins such as misoprostol may augment oxytocic activity, especially when given less than 4 hours prior to oxyto…
Major (7)
- Oxytocin + Cyclopropane— Cyclopropane anesthesia may modify oxytocin's cardiovascular effects, producing unexpected hypotension and maternal sinu…
- Oxytocin + Dopamine Hydrochloride— Concomitant use may result in severe hypertension.
- Oxytocin + Ephedrine Sulfate— Serious postpartum hypertension and stroke reported with concurrent vasopressor and oxytocic use. Carefully monitor bloo…
- Oxytocin + Epinephrine— Potentiates pressor effects of epinephrine.
- Oxytocin + Phenylephrine Hydrochloride— Agonistic effects increase phenylephrine blood pressure effect.
- Oxytocin + Phenylephrine Hydrochloride Injection, Solution— Oxytocin increases pressor effect of phenylephrine hydrochloride.
- Oxytocin + Succinylcholine Chloride— May enhance the neuromuscular blocking action of succinylcholine.
Moderate (2)
- Oxytocin + Epinephrine In Sodium Chloride— Potentiates the effects of epinephrine.
- Oxytocin + Succinylcholine— May enhance the neuromuscular blocking action of succinylcholine.