Home›Oxytocin›Oxytocin + Dinoprostone

Does Oxytocin Interact with Dinoprostone?

Oxytocin and Dinoprostone have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant intravenous use is contraindicated as dinoprostone may augment the activity of oxytocic agents. Remove vaginal insert at least 30 minutes before administering an oxytocic agent. The mechanism involves may augment the activity of oxytocic agents. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Oxytocin Class
Oxytocic
Dinoprostone Class
Prostaglandin Analog
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Oxytocin and Dinoprostone occurs because may augment the activity of oxytocic agents. Clinically, this means concomitant intravenous use is contraindicated as dinoprostone may augment the activity of oxytocic agents. remove vaginal insert at least 30 minutes before administering an oxytocic agent. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Oxytocin and your doctor is considering prescribing Dinoprostone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Oxytocin(Pitocin)+💊 Dinoprostone(Prepidil)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Oxytocic
Drug B class
Prostaglandin Analog
Source
NLP:dinoprostone

What this means in plain English

Concomitant intravenous use is contraindicated as dinoprostone may augment the activity of oxytocic agents. Remove vaginal insert at least 30 minutes before administering an oxytocic agent.

About Oxytocin and Dinoprostone

Oxytocin is an Oxytocic, while Dinoprostone is a Prostaglandin Analog. You may recognize them by the brand names Pitocin and Prepidil. Oxytocin is given by intravenous (IV) infusion, whereas Dinoprostone is given vaginally. Oxytocin additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"May augment the activity of oxytocic agents"

📖 Source: NLP:dinoprostone

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Oxytocin and Dinoprostone against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.