Para-Aminosalicylic Acid has 34 known drug interactions based on U.S. FDA drug labeling data. 28 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Articaine Hydrochloride And Epinephrine, Articaine Hydrochloride And Epinephrine Bitartrate, Benzocaine, Butamben, And Tetracaine Hydrochloride. Patients taking Para-Aminosalicylic Acid should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 34
Major: 28
Moderate: 6

Major (28)

Para-Aminosalicylic Acid + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed to articaine.
Para-Aminosalicylic Acid + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.
Para-Aminosalicylic Acid + Benzocaine, Butamben, And Tetracaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to this antibiotic oxidizing agent with local anesthetics.
Para-Aminosalicylic Acid + Bupivacaine And Meloxicam— Increased risk of methemoglobinemia when local anesthetics are used concomitantly with antibiotics.
Para-Aminosalicylic Acid + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
Para-Aminosalicylic Acid + Dapsone— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
Para-Aminosalicylic Acid + Dapsone Gel, 5%— Concomitant use may increase risk of developing methemoglobinemia. Monitor closely.
Para-Aminosalicylic Acid + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.
Para-Aminosalicylic Acid + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
Para-Aminosalicylic Acid + Lidocaine 5%— Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Para-Aminosalicylic Acid + Lidocaine And Capsaicin— Antibiotic that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
Para-Aminosalicylic Acid + Lidocaine And Prilocaine— Antibiotic; increased risk of methemoglobinemia when concurrently exposed.
Para-Aminosalicylic Acid + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Para-Aminosalicylic Acid + Lidocaine Hydrochloride And Epinephrine Bitartrate— Antibiotic associated with increased methemoglobinemia risk when used concurrently.
Para-Aminosalicylic Acid + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to antibiotics.
Para-Aminosalicylic Acid + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
Para-Aminosalicylic Acid + Lidocaine Patch 5%— Increased risk of methemoglobinemia; antibiotics associated with methemoglobinemia when used with local anesthetics.
Para-Aminosalicylic Acid + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
Para-Aminosalicylic Acid + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to antibiotics.
Para-Aminosalicylic Acid + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antibiotics.
Para-Aminosalicylic Acid + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
Para-Aminosalicylic Acid + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when penicillin is concurrently administered with para-aminosalicylic acid (an antib…
Para-Aminosalicylic Acid + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to para-aminosalicylic acid.
Para-Aminosalicylic Acid + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
Para-Aminosalicylic Acid + Ropivacaine Hydrochloride— Increased risk of developing methemoglobinemia when concurrently exposed to para-aminosalicylic acid.
Para-Aminosalicylic Acid + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed.
Para-Aminosalicylic Acid + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
Para-Aminosalicylic Acid + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch.

Moderate (6)

Para-Aminosalicylic Acid + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
Para-Aminosalicylic Acid + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
Para-Aminosalicylic Acid + Bupivacaine Hydrochloride With Dextrose— Increased risk of developing methemoglobinemia when concurrently exposed.
Para-Aminosalicylic Acid + Lidocaine And Tetracaine— Antibiotic that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
Para-Aminosalicylic Acid + Marcaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antibiotics with bupivacaine.
Para-Aminosalicylic Acid + Prenatal Multivitamin Tablet And Combination Omega-3 Softgel/Mineral Capsule— May decrease the absorption of vitamin B12.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.