Pancuronium has 8 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Deflazacort, Magnesium Sulfate Heptahydrate, Magnesium Sulfate In Dextrose. Patients taking Pancuronium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 4
- Moderate
- 4
Major (4)
- Pancuronium + Deflazacort— Neuromuscular blocking agent. Concomitant use with deflazacort may increase risk of developing acute myopathy.
- Pancuronium + Magnesium Sulfate Heptahydrate— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
- Pancuronium + Magnesium Sulfate In Dextrose— Potentiation and prolongation of neuromuscular blockade is possible. Magnesium suppresses peripheral neuromuscular funct…
- Pancuronium + Vecuronium Bromide— Pancuronium and vecuronium may manifest additive neuromuscular blocking effects when used together due to similar mechan…
Moderate (4)
- Pancuronium + Desflurane— Desflurane reduces ED95 of pancuronium by approximately 50%. Dose adjustment may be needed during maintenance anesthesia…
- Pancuronium + Isoflurane— Isoflurane potentiates the muscle relaxant effect of pancuronium, reducing required ED95 by approximately 25-40%. Dose a…
- Pancuronium + Sevoflurane— Sevoflurane increases both the intensity and duration of neuromuscular blockade induced by pancuronium. Dosage adjustmen…
- Pancuronium + Trospium Chloride— May increase serum concentration of trospium and/or pancuronium due to competition for renal tubular secretion. Careful …