Penicillamine has 7 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Digoxin, Polyethylene Glycol 3350, Sodium Sulfate, Potassium Chloride, Magnesium Sulfate, And Sodium Chloride For Oral Solution, Sodium Picosulfate, Magnesium Oxide, And Anhydrous Citric Acid. Patients taking Penicillamine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Moderate
- 6
- Minor
- 1
Moderate (6)
- Penicillamine + Digoxin— Decreases digoxin concentrations. Requires monitoring and dose adjustment.
- Penicillamine + Polyethylene Glycol 3350, Sodium Sulfate, Potassium Chloride, Magnesium Sulfate, And Sodium Chloride For Oral Solution— SUFLAVE can reduce absorption of penicillamine. Administer at least 2 hours before and not less than 6 hours after SUFLA…
- Penicillamine + Sodium Picosulfate, Magnesium Oxide, And Anhydrous Citric Acid— Reduced absorption of penicillamine due to chelation with magnesium. Administer at least 2 hours before and not less tha…
- Penicillamine + Sodium Sulfate Anhydrous, Potassium Sulfate, And Magnesium Sulfate— Sodium sulfate, potassium sulfate, and magnesium sulfate oral solution can reduce absorption of penicillamine via chelat…
- Penicillamine + Sodium Sulfate, Magnesium Sulfate, And Potassium Chloride— Reduced absorption due to chelation with magnesium. Administer at least 2 hours before and not less than 6 hours after S…
- Penicillamine + Sodium Sulfate, Potassium Sulfate, Magnesium Sulfate— Administer at least 2 hours before and not less than 6 hours after SUPREP to avoid chelation with magnesium and reduced …
Minor (1)
- Penicillamine + Zinc Acetate— Pharmacodynamic studies in Wilson's disease patients showed no drug interactions between zinc acetate and penicillamine.…