Penicillin G has 21 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Colestipol Hydrochloride, Acetazolamide, Andthiazide. Patients taking Penicillin G should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Major
- 1
- Moderate
- 17
Major (1)
- Penicillin G + Colestipol Hydrochloride— Absorption of penicillin G is significantly decreased when given simultaneously with colestipol hydrochloride.
Moderate (17)
- Penicillin G + Acetazolamide— Bacteriostatic antibacterial may antagonize the bactericidal effect of penicillin and may compete for renal tubular secr…
- Penicillin G + Andthiazide— Compete with penicillin G for renal tubular secretion, prolonging serum half-life.
- Penicillin G + Aspirin— Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
- Penicillin G + Chloramphenicol— Bacteriostatic antibacterial may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.
- Penicillin G + Cholestyramine Light— Cholestyramine may delay or reduce the absorption of penicillin G.
- Penicillin G + Cholestyramine Powder For Suspension— Cholestyramine may delay or reduce the absorption of penicillin G.
- Penicillin G + Choleystyramine Light— Cholestyramine may delay or reduce absorption of penicillin G.
- Penicillin G + Erythromycin— Bacteriostatic antibacterial may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.
- Penicillin G + Ethacrynic Acid— Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
- Penicillin G + Furosemide— Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
- Penicillin G + Indomethacin— Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
- Penicillin G + Leflunomide— Exposure to penicillin G may be increased when coadministered with leflunomide. Monitor and adjust dose as required.
- Penicillin G + Leflunomide And Diclofenac Sodium Gel— Exposure of penicillin G may be increased in patients taking leflunomide. Monitor and adjust dose as required.
- Penicillin G + Phenylbutazone— Competes with penicillin G for renal tubular secretion, prolonging serum half-life.
- Penicillin G + Probenecid— Blocks renal tubular secretion of penicillins, prolonging penicillin blood levels and serum half-life.
- Penicillin G + Teriflunomide— Teriflunomide may increase exposure of penicillin G. Monitor patients and adjust dose as required.
- Penicillin G + Tetracycline— Bacteriostatic antibacterial may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.