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Penicillin G Benzathine

Also known as: Bicillin L-A

Route: Intramuscular

Check Penicillin G Benzathine Interactions →

8 interactions on record⛔ Black Box Warning

Penicillin G Benzathine has 8 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methotrexate, Chloramphenicol, Erythromycin. Patients taking Penicillin G Benzathine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 8
Major: 1
Moderate: 5

Major (1)

Penicillin G Benzathine + Methotrexate— Penicillin G benzathine may reduce the renal excretion of methotrexate, causing a potential increase in its toxicity.

Moderate (5)

Penicillin G Benzathine + Chloramphenicol— Chloramphenicol may antagonize the bactericidal effect of penicillin G benzathine by interfering with active bacterial g…
Penicillin G Benzathine + Erythromycin— Erythromycin may antagonize the bactericidal effect of penicillin G benzathine by interfering with active bacterial grow…
Penicillin G Benzathine + Oral Contraceptives— Penicillin G benzathine may impair the efficacy of oral contraceptives, potentially resulting in unwanted pregnancy. Alt…
Penicillin G Benzathine + Probenecid— Probenecid increases and prolongs serum penicillin levels by decreasing volume of distribution and slowing excretion.
Penicillin G Benzathine + Tetracycline— Tetracycline may antagonize the bactericidal effect of penicillin; concurrent use should be avoided.

Penicillin G Benzathine + Methotrexate⚠️Major

Penicillin G benzathine may reduce the renal excretion of methotrexate, causing a potential increase in its toxicity.

Penicillin G Benzathine + Chloramphenicol🟡Moderate

Chloramphenicol may antagonize the bactericidal effect of penicillin G benzathine by interfering with active bacterial growth necessary for penicillin's effect.

Penicillin G Benzathine + Erythromycin🟡Moderate

Erythromycin may antagonize the bactericidal effect of penicillin G benzathine by interfering with active bacterial growth necessary for penicillin's effect.

Penicillin G Benzathine + Oral Contraceptives🟡Moderate

Penicillin G benzathine may impair the efficacy of oral contraceptives, potentially resulting in unwanted pregnancy. Alternative contraception methods should be considered.

Penicillin G Benzathine + Probenecid🟡Moderate

Probenecid increases and prolongs serum penicillin levels by decreasing volume of distribution and slowing excretion.

Penicillin G Benzathine + Tetracycline🟡Moderate

Tetracycline may antagonize the bactericidal effect of penicillin; concurrent use should be avoided.

Penicillin G Benzathine + Penicillinℹ️Unknown

Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided. Concurrent administration of penicillin and probenecid increases and prolongs serum penicillin levels by decreasing the apparent volume of distribution and slowing the rate of excretion by competitively inhibiting renal tubular secretion of penicillin.

Penicillin G Benzathine + Penicillin Gℹ️Unknown

Bacteriostatic antibiotics: Bacteriostatic antibiotics, such as tetracycline, erythromycin and chloramphenicol, may antagonize the bactericidal effect of benzylpenicillin by interfering with active bacterial growth necessary to benzylpenicillin’s effect. Oral contraceptives: The efficacy of oral contraceptives may be impaired in case of concomitant therapy with benzylpenicillin, which may result in an unwanted pregnancy. Probenecid: Probenecid decreases the renal tubular secretion of benzylpenicillin.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.