Home›Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine

Also known as: Bl-C Kit

Route: Infiltration, Intra-Articular, Intralesional, Intramuscular, Intravascular, Perineural, Topical

Check Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine Interactions →

34 interactions on record⛔ Black Box Warning

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine has 34 known drug interactions based on U.S. FDA drug labeling data. 23 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aminoglutethimide, Amphotericin B, Anticholinesterase Agents. Patients taking Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 34
Major: 23
Moderate: 11

Major (23)

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Aminoglutethimide— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Amphotericin B— Concomitant use with corticosteroids may cause hypokalemia, cardiac enlargement, and congestive heart failure.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Anticholinesterase Agents— Concomitant use may produce severe weakness in patients with myasthenia gravis.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Clarithromycin— Strong CYP3A4 inhibitor may increase corticosteroid exposure and risk of systemic side effects; monitor closely.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cobicistat— Strong CYP3A4 inhibitor in cobicistat-containing products may increase corticosteroid exposure and risk of systemic side…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cyclophosphamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cyclosporine— Increased activity of both agents may occur concurrently. Convulsions have been reported.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Digitalis Glycosides— Patients may be at increased risk of arrhythmias due to hypokalemia induced by corticosteroids.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ergot-Type Oxytocic Drugs— May cause severe, persistent hypertension or cerebrovascular accidents. Avoid concurrent use.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Flutamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ifosfamide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Itraconazole— Strong CYP3A4 inhibitor may increase corticosteroid exposure and risk of systemic side effects; monitor closely.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ketoconazole— Decreases metabolism of betamethasone by up to 60%, leading to increased risk of corticosteroid side effects.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Macrolide Antibiotics— Macrolide antibiotics cause significant decrease in corticosteroid clearance, potentially increasing corticosteroid effe…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Metformin— Iodixanol may increase risk of metformin-induced lactic acidosis, possibly by worsening renal function. Stop metformin b…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Metoclopramide— Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitro…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Monoamine Oxidase Inhibitors (Maois)— May produce severe, prolonged hypertension. Concurrent use should generally be avoided.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Nonselective Beta-Adrenergic Antagonists— May cause severe hypertension and bradycardia. Concurrent use should generally be avoided.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Oral Cholecystographic Contrast Agents— Renal toxicity reported in patients with liver dysfunction receiving oral cholecystographic agent followed by iodixanol.…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Radioactive Iodine— Iodixanol may interfere with thyroid uptake of radioactive iodine (I-131, I-123), decreasing therapeutic and diagnostic …
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ritonavir— Strong CYP3A4 inhibitor may increase corticosteroid exposure and risk of systemic side effects; monitor closely.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Topical Local Anesthetics— Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor are used during or followi…
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Warfarin— Coadministration usually results in inhibition of response to warfarin; coagulation indices should be monitored frequent…

Moderate (11)

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Acetylsalicylic Acid— Concomitant use of aspirin or other NSAIDs with corticosteroids requires monitoring.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Acidifying Agents— Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Barbiturates— Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Carbamazepine— Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cholestyramine Light— May increase the clearance of corticosteroids.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Estrogens— May decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Isoniazid— Serum concentrations of isoniazid may be decreased by corticosteroids.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Oral Contraceptives— Oral contraceptives may decrease hepatic metabolism of certain corticosteroids, increasing their effect.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Phenytoin— Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Rifampin— Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.
Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Salicylates— Clearance of salicylates may be increased with concurrent corticosteroid use.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Aminoglutethimide⚠️Major

Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Amphotericin B⚠️Major

Concomitant use with corticosteroids may cause hypokalemia, cardiac enlargement, and congestive heart failure.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Anticholinesterase Agents⚠️Major

Concomitant use may produce severe weakness in patients with myasthenia gravis.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Clarithromycin⚠️Major

Strong CYP3A4 inhibitor may increase corticosteroid exposure and risk of systemic side effects; monitor closely.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cobicistat⚠️Major

Strong CYP3A4 inhibitor in cobicistat-containing products may increase corticosteroid exposure and risk of systemic side effects.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cyclophosphamide⚠️Major

Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine 7.6 Potent Inhalation Anesthetics Serious dose-related cardiac arrhythmias may occur if preparations containing a vasoconstrictor such as epinephrine (e.g., Bupivacaine Hydrochloride and Epinephrine Injection) are used in patients during or following the administration of potent inhalation anesthetics [see Warnings and Precautions (5.13) ] .

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cyclosporine⚠️Major

Increased activity of both agents may occur concurrently. Convulsions have been reported.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Digitalis Glycosides⚠️Major

Patients may be at increased risk of arrhythmias due to hypokalemia induced by corticosteroids.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ergot-Type Oxytocic Drugs⚠️Major

May cause severe, persistent hypertension or cerebrovascular accidents. Avoid concurrent use.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Flutamide⚠️Major

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ifosfamide⚠️Major

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Itraconazole⚠️Major

Strong CYP3A4 inhibitor may increase corticosteroid exposure and risk of systemic side effects; monitor closely.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ketoconazole⚠️Major

Decreases metabolism of betamethasone by up to 60%, leading to increased risk of corticosteroid side effects.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Macrolide Antibiotics⚠️Major

Macrolide antibiotics cause significant decrease in corticosteroid clearance, potentially increasing corticosteroid effects.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Metformin⚠️Major

Iodixanol may increase risk of metformin-induced lactic acidosis, possibly by worsening renal function. Stop metformin before iodixanol administration in patients with renal impairment, hepatic impairment, alcoholism, or heart failure.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Metoclopramide⚠️Major

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Monoamine Oxidase Inhibitors (Maois)⚠️Major

May produce severe, prolonged hypertension. Concurrent use should generally be avoided.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Nonselective Beta-Adrenergic Antagonists⚠️Major

May cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Oral Cholecystographic Contrast Agents⚠️Major

Renal toxicity reported in patients with liver dysfunction receiving oral cholecystographic agent followed by iodixanol. Postpone iodixanol administration in recent users.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Radioactive Iodine⚠️Major

Iodixanol may interfere with thyroid uptake of radioactive iodine (I-131, I-123), decreasing therapeutic and diagnostic efficacy in thyroid carcinoma patients for 6-8 weeks.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Ritonavir⚠️Major

Strong CYP3A4 inhibitor may increase corticosteroid exposure and risk of systemic side effects; monitor closely.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Topical Local Anesthetics⚠️Major

Serious dose-related cardiac arrhythmias may occur if preparations containing vasoconstrictor are used during or following administration.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Warfarin⚠️Major

Coadministration usually results in inhibition of response to warfarin; coagulation indices should be monitored frequently.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Acetylsalicylic Acid🟡Moderate

Concomitant use of aspirin or other NSAIDs with corticosteroids requires monitoring.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Acidifying Agents🟡Moderate

Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Barbiturates🟡Moderate

Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Carbamazepine🟡Moderate

Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Cholestyramine Light🟡Moderate

May increase the clearance of corticosteroids.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Estrogens🟡Moderate

May decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Isoniazid🟡Moderate

Serum concentrations of isoniazid may be decreased by corticosteroids.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Oral Contraceptives🟡Moderate

Oral contraceptives may decrease hepatic metabolism of certain corticosteroids, increasing their effect.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Phenytoin🟡Moderate

Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Rifampin🟡Moderate

Hepatic enzyme induction may enhance corticosteroid metabolism, requiring increased corticosteroid dosage.

Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Iodixanol, Povidine Iodine + Salicylates🟡Moderate

Clearance of salicylates may be increased with concurrent corticosteroid use.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.