Phentolamine has 8 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Adrenalin (Epinephrine), Albuterol Sulfate, Epinephrine. Patients taking Phentolamine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 5
- Moderate
- 3
Major (5)
- Phentolamine + Adrenalin (Epinephrine)— Alpha-adrenergic blocking drugs antagonize the vasoconstricting and hypertensive effects of epinephrine.
- Phentolamine + Albuterol Sulfate— Alpha-adrenergic blocking drugs antagonize the vasoconstricting and hypertensive effects of epinephrine.
- Phentolamine + Epinephrine— Alpha-adrenergic blocking drugs antagonize the vasoconstricting and hypertensive effects of epinephrine.
- Phentolamine + Epinephrine 0.15 Pediatrics— Vasoconstricting and hypertensive effects of epinephrine are antagonized by alpha-adrenergic blocking drug phentolamine.
- Phentolamine + Epinephrine 0.3 Adults— Alpha-adrenergic blocking drug phentolamine antagonizes vasoconstricting and hypertensive effects of epinephrine.
Moderate (3)
- Phentolamine + Auvi-Q— Alpha-adrenergic blocker that antagonizes the vasoconstricting and hypertensive effects of epinephrine.
- Phentolamine + Epinephrine In Sodium Chloride— Alpha blocker that counters the pressor effects of epinephrine.
- Phentolamine + Promethazine Hydrochloride And Phenylephrine Hydrochloride— α-adrenergic blockers decrease phenylephrine pressor response.