Phenylephrine Hydrochloride has 31 known drug interactions based on U.S. FDA drug labeling data. 24 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Adrenergic Blockers, Aldosterone, Amiodarone. Patients taking Phenylephrine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 31
- Major
- 24
- Moderate
- 5
- Minor
- 2
Major (24)
- Phenylephrine Hydrochloride + Adrenergic Blockers— Increase the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Aldosterone— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Amiodarone— α-adrenergic blocking agent that blocks phenylephrine and is in turn blocked by phenylephrine.
- Phenylephrine Hydrochloride + Anakinra— Antagonistic effects with decreased phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Angiotensin Ii— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Atomoxetine— Norepinephrine transport inhibitor that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Atropine— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Atropine Sulfate— Increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Chlorpromazine— α-adrenergic blocking agent (phenothiazine) that blocks phenylephrine and is in turn blocked by phenylephrine.
- Phenylephrine Hydrochloride + Clonidine— α-2 adrenergic agonist that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Ergot Alkaloids— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Guanfacine— Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Hydrocortisone— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Mao Inhibitors— Antagonistic effects with decreased phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Methyl Ergonovine Maleate— Methyl ergonovine maleate (ergot alkaloid) increases phenylephrine blood pressure effect through agonistic interaction, …
- Phenylephrine Hydrochloride + Methylergonovine Maleate— Ergot alkaloid that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Nifedipine— Antagonistic effects with decreased phenylephrine blood pressure effect via calcium channel blockade.
- Phenylephrine Hydrochloride + Nitrazepam— Antagonistic effects with decreased phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Norepinephrine— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Oxytocin— Agonistic effects increase phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Reserpine— Centrally-acting sympatholytic agent that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Selegiline— Monoamine oxidase inhibitor that increases the pressor effect of phenylephrine hydrochloride.
- Phenylephrine Hydrochloride + Topical Steroids— Increase the pressor effect of phenylephrine hydrochloride.
Moderate (5)
- Phenylephrine Hydrochloride + Alpha-Blockers— Alpha-adrenergic antagonists decrease phenylephrine blood pressure effect through antagonistic interaction.
- Phenylephrine Hydrochloride + Calcium Channel Blockers— Antagonistic effects decrease phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Centrally Acting Drugs— Antagonistic effects decrease phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Mixed Alpha- And Beta-Receptor Antagonists— Mixed alpha- and beta-receptor antagonists decrease phenylephrine blood pressure effect.
- Phenylephrine Hydrochloride + Topical Local Anesthetics— Phenylephrine may potentiate the cardiovascular depressant effects of inhalation anesthetic agents.
Minor (2)
- Phenylephrine Hydrochloride + Terazosin— Terazosin has been used concomitantly with phenylephrine hydrochloride in at least 50 patients with no interactions obse…
- Phenylephrine Hydrochloride + Terazosin Hydrochloride— Used concomitantly with terazosin in at least 50 patients with no interactions observed.