Amphetamine Sulfate has 26 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 14 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Furazolidone, Mao Inhibitors, Acetazolamide. Patients taking Amphetamine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 26
- Contraindicated
- 2
- Major
- 14
- Moderate
- 9
Contraindicated (2)
- Amphetamine Sulfate + Furazolidone— Furazolidone metabolite slows amphetamine metabolism, potentiating effects and risking hypertensive crisis, neurological…
- Amphetamine Sulfate + Mao Inhibitors— MAOIs slow amphetamine metabolism, potentiating effects and risk of hypertensive crisis, neurological toxicity, and pote…
Major (14)
- Amphetamine Sulfate + Acetazolamide— Urinary alkalinizing agent that decreases amphetamine excretion by increasing non-ionized species, elevating blood level…
- Amphetamine Sulfate + Buspirone— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
- Amphetamine Sulfate + Desipramine— Tricyclic antidepressant that causes striking and sustained increases in brain d-amphetamine concentration with potentia…
- Amphetamine Sulfate + Fentanyl— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
- Amphetamine Sulfate + Fluoxetine— Concomitant use increases risk of serotonin syndrome and increases amphetamine exposure via CYP2D6 inhibition.
- Amphetamine Sulfate + Lithium— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
- Amphetamine Sulfate + Paroxetine— Concomitant use increases risk of serotonin syndrome and increases amphetamine exposure via CYP2D6 inhibition.
- Amphetamine Sulfate + Protriptyline— Tricyclic antidepressant that causes striking and sustained increases in brain d-amphetamine concentration with potentia…
- Amphetamine Sulfate + Quinidine— CYP2D6 inhibitor that increases amphetamine exposure and serotonin syndrome risk.
- Amphetamine Sulfate + Ritonavir— CYP2D6 inhibitor that increases amphetamine exposure and serotonin syndrome risk.
- Amphetamine Sulfate + Sodium Bicarbonate— Gastrointestinal alkalinizing agent that increases amphetamine absorption and blood levels, potentiating amphetamine act…
- Amphetamine Sulfate + St. John'S Wort— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
- Amphetamine Sulfate + Tramadol— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
- Amphetamine Sulfate + Tryptophan— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
Moderate (9)
- Amphetamine Sulfate + Adrenergic Blockers— Amphetamines inhibit the effects of adrenergic blockers.
- Amphetamine Sulfate + Ammonium Chloride— Urinary acidifying agent that increases ionized amphetamine species and urinary excretion, lowering blood levels and eff…
- Amphetamine Sulfate + Antihistamines— Amphetamines may counteract the sedative effects of antihistamines.
- Amphetamine Sulfate + Ascorbic Acid— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Amphetamine Sulfate + Chlorpromazine— Blocks dopamine and norepinephrine reuptake, potentially inhibiting central stimulant effects of amphetamine.
- Amphetamine Sulfate + Glutamic Acid Hcl— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Amphetamine Sulfate + Guanethidine— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Amphetamine Sulfate + Reserpine— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Amphetamine Sulfate + Sodium Acid Phosphate— Urinary acidifying agent that increases ionized amphetamine species and urinary excretion, lowering blood levels and eff…