Clindamycin Hydrochloride has 5 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Erythromycin, Adrenergic Blockers, Mao Inhibitors. Patients taking Clindamycin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Contraindicated
- 1
- Moderate
- 3
- Minor
- 1
Contraindicated (1)
- Clindamycin Hydrochloride + Erythromycin— Antagonism demonstrated between clindamycin and erythromycin in vitro; these two drugs should not be administered concur…
Moderate (3)
- Clindamycin Hydrochloride + Adrenergic Blockers— Clindamycin has neuromuscular blocking properties that may enhance the action of neuromuscular blocking agents; use with…
- Clindamycin Hydrochloride + Mao Inhibitors— CYP3A4 inhibitors may increase plasma concentrations of clindamycin. Monitor for adverse reactions in the presence of st…
- Clindamycin Hydrochloride + Rifampin— Strong CYP3A4 inducer may reduce plasma concentrations of clindamycin; monitor for loss of effectiveness.
Minor (1)
- Clindamycin Hydrochloride + Clindamycin— Drug Interactions Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of ot…