Demeclocycline Hydrochloride has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methoxyflurane, Penicillin, Tetracycline. Patients taking Demeclocycline Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 1
- Major
- 2
- Moderate
- 4
Contraindicated (1)
- Demeclocycline Hydrochloride + Methoxyflurane— Concurrent use of tetracyclines and methoxyflurane has been reported to result in fatal renal toxicity.
Major (2)
- Demeclocycline Hydrochloride + Penicillin— Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving te…
- Demeclocycline Hydrochloride + Tetracycline— Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anti…
Moderate (4)
- Demeclocycline Hydrochloride + Antacids Containing Calcium, Magnesium, Or Aluminum— Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium.
- Demeclocycline Hydrochloride + Iron-Containing Preparations— Absorption of tetracyclines is impaired by iron-containing preparations.
- Demeclocycline Hydrochloride + Oral Anticoagulants— Tetracyclines depress plasma prothrombin activity; patients may require downward adjustment of anticoagulant dosage.
- Demeclocycline Hydrochloride + Oral Contraceptives— Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective.