Phentermine Hydrochloride has 5 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Monoamine Oxidase Inhibitors (Maois), Adrenergic Blockers, Alcohol. Patients taking Phentermine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Contraindicated
- 1
- Moderate
- 4
Contraindicated (1)
- Phentermine Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Contraindicated during or within 14 days of MAOI administration due to risk of hypertensive crisis.
Moderate (4)
- Phentermine Hydrochloride + Adrenergic Blockers— Phentermine may decrease the hypotensive effect of these agents.
- Phentermine Hydrochloride + Alcohol— Concomitant use may result in adverse drug reaction.
- Phentermine Hydrochloride + Insulin Human— Requirements may be altered when used with phentermine.
- Phentermine Hydrochloride + Topiramate— In the presence of topiramate, phentermine Cmax and AUC increase by 13% and 42% respectively.