Trazodone Hydrochloride has 35 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 18 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Isocarboxazid, Linezolid, Maois. Patients taking Trazodone Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 35
- Contraindicated
- 8
- Major
- 18
- Moderate
- 6
Contraindicated (8)
- Trazodone Hydrochloride + Isocarboxazid— Concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated in patients taking MAOIs.
- Trazodone Hydrochloride + Linezolid— Concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated with linezolid and intravenous methyl…
- Trazodone Hydrochloride + Maois— MAOIs should not be used within 14 days of trazodone due to risk of serotonin syndrome.
- Trazodone Hydrochloride + Methylene Blue— Intravenous methylene blue concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated.
- Trazodone Hydrochloride + Moclobemide— Concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated in patients taking MAOIs.
- Trazodone Hydrochloride + Phenelzine— Concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated in patients taking MAOIs.
- Trazodone Hydrochloride + Selegiline— Concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated in patients taking MAOIs.
- Trazodone Hydrochloride + Tranylcypromine— Concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated in patients taking MAOIs.
Major (18)
- Trazodone Hydrochloride + Buspirone— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + Carbamazepine— CYP3A4 inducer that reduces trazodone and active metabolite plasma concentrations by 76% and 60%, respectively; dose inc…
- Trazodone Hydrochloride + Clarithromycin— Strong CYP3A4 inhibitor increases trazodone exposure, increasing risk of adverse reactions including cardiac arrhythmias…
- Trazodone Hydrochloride + Clopidogrel— Increased risk of bleeding due to serotonin effects on platelet hemostasis with antiplatelet agent use.
- Trazodone Hydrochloride + Dabigatran— Increased risk of bleeding due to serotonin effects on platelet hemostasis with anticoagulant use.
- Trazodone Hydrochloride + Fentanyl— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + Indinavir— Strong CYP3A4 inhibitor increases trazodone exposure, increasing risk of adverse reactions including cardiac arrhythmias…
- Trazodone Hydrochloride + Itraconazole— Strong CYP3A4 inhibitor increases trazodone exposure, increasing risk of adverse reactions including cardiac arrhythmias…
- Trazodone Hydrochloride + Ketoconazole— Strong CYP3A4 inhibitor increases trazodone exposure, increasing risk of adverse reactions including cardiac arrhythmias…
- Trazodone Hydrochloride + Lithium— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + Ritonavir— Ritonavir increases trazodone AUC 2.4-fold, half-life 2.2-fold, with adverse effects including nausea, hypotension, and …
- Trazodone Hydrochloride + Rivaroxaban— Increased risk of bleeding due to serotonin effects on platelet hemostasis with anticoagulant use.
- Trazodone Hydrochloride + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + St. John'S Wort— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + Tramadol— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + Triptans— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + Tryptophan— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Trazodone Hydrochloride + Warfarin— Increased risk of bleeding due to serotonin effects on platelet hemostasis. Monitor INR when initiating or discontinuing…
Moderate (6)
- Trazodone Hydrochloride + Acetylsalicylic Acid— Concomitant use with trazodone may increase risk of gastrointestinal bleeding. Monitor patients for bleeding risk.
- Trazodone Hydrochloride + Alcohol— Trazodone may enhance effects of alcohol and other CNS depressants.
- Trazodone Hydrochloride + Barbiturates— Trazodone may enhance effects of barbiturates and other CNS depressants.
- Trazodone Hydrochloride + Digoxin— Monitor for increased digoxin serum levels when used concomitantly with trazodone.
- Trazodone Hydrochloride + Phenytoin— Monitor for increased phenytoin serum levels when used concomitantly with trazodone.
- Trazodone Hydrochloride + Rifampin— Strong CYP3A4 inducer decreases trazodone exposure. Monitor closely and consider increased trazodone dose.