Mefloquine Hydrochloride has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Halofantrine, Ketoconazole, Chloroquine. Patients taking Mefloquine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 2
- Major
- 4
- Moderate
- 5
Contraindicated (2)
- Mefloquine Hydrochloride + Halofantrine— Should not be administered with mefloquine or within 15 weeks of last mefloquine dose due to risk of potentially fatal Q…
- Mefloquine Hydrochloride + Ketoconazole— Should not be administered with mefloquine or within 15 weeks of last mefloquine dose due to risk of potentially fatal Q…
Major (4)
- Mefloquine Hydrochloride + Chloroquine— Concomitant administration may produce electrocardiographic abnormalities and increase risk of convulsions. Delay mefloq…
- Mefloquine Hydrochloride + Propranolol— One report of cardiopulmonary arrest with full recovery in a patient taking propranolol with mefloquine. Effects on comp…
- Mefloquine Hydrochloride + Quinidine— Concomitant administration may produce electrocardiographic abnormalities and increase risk of convulsions. Delay mefloq…
- Mefloquine Hydrochloride + Quinine— Concomitant administration may produce electrocardiographic abnormalities and increase risk of convulsions. Delay mefloq…
Moderate (5)
- Mefloquine Hydrochloride + Carbamazepine— Mefloquine may reduce seizure control by lowering plasma levels of anticonvulsant. Monitor blood levels and adjust dosag…
- Mefloquine Hydrochloride + Live Vaccines— Attenuation of immunization cannot be excluded when mefloquine taken concurrently. Complete vaccinations with attenuated…
- Mefloquine Hydrochloride + Phenobarbital— Mefloquine may reduce seizure control by lowering plasma levels of anticonvulsant. Monitor blood levels and adjust dosag…
- Mefloquine Hydrochloride + Phenytoin— Mefloquine may reduce seizure control by lowering plasma levels of anticonvulsant. Monitor blood levels and adjust dosag…
- Mefloquine Hydrochloride + Valproic Acid— Mefloquine may reduce seizure control by lowering plasma levels of anticonvulsant. Monitor blood levels and adjust dosag…