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Piperacillin

3 interactions on record

Piperacillin has 3 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Piperacillin And Tazobactam, Vancomycin, Vancomycin Hydrochloride. Patients taking Piperacillin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Moderate: 3

Moderate (3)

Piperacillin + Piperacillin And Tazobactam— 7 DRUG INTERACTIONS Piperacillin and Tazobactam for Injection administration can significantly reduce tobramycin concent…
Piperacillin + Vancomycin— ( 2.1 , 7.1 ) Piperacillin/Tazobactam : Increased incidence of acute kidney injury in patients receiving concomitant pip…
Piperacillin + Vancomycin Hydrochloride— ( 2.1 , 7.1 ) • Piperacillin/Tazobactam : Increased incidence of acute kidney injury in patients receiving concomitant p…

Piperacillin + Piperacillin And Tazobactam🟡Moderate

7 DRUG INTERACTIONS Piperacillin and Tazobactam for Injection administration can significantly reduce tobramycin concentrations in hemodialysis patients. ( 7.1 ) Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with Piperacillin and Tazobactam for Injection unless the benefit outweighs the risk. ( 7.2 ) Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and heparin or oral anticoagulants.

Piperacillin + Vancomycin🟡Moderate

( 2.1 , 7.1 ) Piperacillin/Tazobactam : Increased incidence of acute kidney injury in patients receiving concomitant piperacillin/tazobactam and vancomycin as compared to vancomycin alone. 7.2 Piperacillin-Tazobactam Studies have detected an increased incidence of acute kidney injury in patients administered concomitant piperacillin/tazobactam and vancomycin as compared to vancomycin alone. Monitor kidney function in patients receiving concomitant piperacillin/tazobactam and TYZAVAN.

Piperacillin + Vancomycin Hydrochloride🟡Moderate

( 2.1 , 7.1 ) • Piperacillin/Tazobactam : Increased incidence of acute kidney injury in patients receiving concomitant piperacillin/tazobactam and vancomycin as compared to vancomycin alone. 7.2 Piperacillin-Tazobactam Studies have detected an increased incidence of acute kidney injury in patients administered concomitant piperacillin/tazobactam and vancomycin as compared to vancomycin alone. Monitor kidney function in patients receiving concomitant piperacillin/tazobactam and vancomycin.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.