Delavirdine has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Etravirine, Methylergonovine Maleate, Rifabutin. Patients taking Delavirdine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Contraindicated
- 3
- Major
- 1
- Moderate
- 5
Contraindicated (3)
- Delavirdine + Etravirine— Etravirine and delavirdine should not be co-administered. Combining two NNRTIs has not been shown to be beneficial.
- Delavirdine + Methylergonovine Maleate— Potent CYP 3A4 inhibitor (HIV reverse transcriptase inhibitor); rare reports of serious adverse events including vasospa…
- Delavirdine + Rifabutin— Delavirdine increases rifabutin AUC by 230% and Cmax by 128%, while rifabutin reduces delavirdine concentrations by 80%.…
Major (1)
- Delavirdine + Nimodipine— Strong CYP3A4 inhibitor that significantly increases nimodipine plasma concentration and blood pressure lowering effect.…
Moderate (5)
- Delavirdine + Carbamazepine— CYP3A4 inhibitor that increases plasma levels of carbamazepine; dose adjustment and/or plasma level monitoring may be ne…
- Delavirdine + Nelfinavir Mesylate— Coadministration increases nelfinavir concentrations while decreasing delavirdine concentrations. Appropriate combinatio…
- Delavirdine + Propranolol Hydrochloride— CYP2D6 inhibitor that may increase blood levels of propranolol.
- Delavirdine + Ranitidine— Delavirdine absorption may be impaired with ranitidine due to increased gastric pH. Chronic H2-receptor antagonist use w…
- Delavirdine + Ranitidine Hydrochloride— Delavirdine absorption may be impaired with ranitidine. Chronic use of H2-receptor antagonists with delavirdine is not r…