Rosiglitazone has 6 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Gemfibrozil, Leflunomide, Leflunomide And Diclofenac Sodium Gel. Patients taking Rosiglitazone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Moderate
- 6
Moderate (6)
- Rosiglitazone + Gemfibrozil— Gemfibrozil is a strong CYP2C8 inhibitor that may increase rosiglitazone exposure; dosing reduction may be required.
- Rosiglitazone + Leflunomide— Exposure to rosiglitazone may be increased when coadministered with leflunomide. Monitor and adjust dose as required.
- Rosiglitazone + Leflunomide And Diclofenac Sodium Gel— Exposure of rosiglitazone may be increased in patients taking leflunomide. Monitor and adjust dose as required.
- Rosiglitazone + Paclitaxel— CYP2C8 substrate; caution should be exercised when administering paclitaxel concomitantly.
- Rosiglitazone + Sulfamethoxazole And Trimethoprim— BACTRIM potentiates oral hypoglycemic effects of rosiglitazone. Additional blood glucose monitoring warranted.
- Rosiglitazone + Teriflunomide— Teriflunomide may increase exposure of rosiglitazone. Monitor patients and adjust dose as required.