Everolimus Tablets has 25 known drug interactions based on U.S. FDA drug labeling data. Of these, 10 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Boceprevir, Clarithromycin, Itraconazole. Patients taking Everolimus Tablets should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Contraindicated
- 10
- Major
- 5
- Moderate
- 5
Contraindicated (10)
- Everolimus Tablets + Boceprevir— Strong CYP3A4 inhibitor; co-administration with everolimus is not recommended.
- Everolimus Tablets + Clarithromycin— Strong CYP3A4 inhibitor; co-administration with everolimus is not recommended.
- Everolimus Tablets + Itraconazole— Strong CYP3A4 inhibitor; co-administration with everolimus is not recommended.
- Everolimus Tablets + Ketoconazole— Strong CYP3A4 inhibitor significantly increases everolimus Cmax, AUC, and half-life; co-administration is not recommende…
- Everolimus Tablets + Rifabutin— Strong CYP3A4 inducer; co-administration with everolimus is not recommended.
- Everolimus Tablets + Rifampin— Strong CYP3A4 inducer; co-administration with everolimus is not recommended.
- Everolimus Tablets + Ritonavir— Strong CYP3A4 inhibitor; co-administration with everolimus is not recommended.
- Everolimus Tablets + Telaprevir— Strong CYP3A4 inhibitor; co-administration with everolimus is not recommended.
- Everolimus Tablets + Telithromycin— Strong CYP3A4 inhibitor; co-administration with everolimus is not recommended.
- Everolimus Tablets + Voriconazole— Strong CYP3A4 inhibitor; co-administration with everolimus is not recommended.
Major (5)
- Everolimus Tablets + Cannabidiol— Therapeutic drug monitoring and dose reduction for everolimus should be considered when co-administered with cannabidiol…
- Everolimus Tablets + Cyclosporine— Cyclosporine significantly increases everolimus Cmax and AUC; dose adjustment of everolimus may be needed if cyclosporin…
- Everolimus Tablets + Digoxin— P-glycoprotein inhibitor may decrease everolimus efflux from intestinal cells and increase everolimus blood concentratio…
- Everolimus Tablets + Erythromycin— Moderate CYP3A4 inhibitor significantly increases everolimus Cmax, AUC, and half-life; dose adjustment should be conside…
- Everolimus Tablets + Verapamil— CYP3A4 inhibitor may affect everolimus concentrations; dose adjustment should be considered.
Moderate (5)
- Everolimus Tablets + Amprenavir— 7.10 Other Possible Interactions Moderate inhibitors of CYP3A4 and P-gp may increase everolimus blood concentrations (e.…
- Everolimus Tablets + Fluconazole— 7.10 Other Possible Interactions Moderate inhibitors of CYP3A4 and P-gp may increase everolimus blood concentrations (e.…
- Everolimus Tablets + Indinavir— 7.10 Other Possible Interactions Moderate inhibitors of CYP3A4 and P-gp may increase everolimus blood concentrations (e.…
- Everolimus Tablets + Nelfinavir— 7.10 Other Possible Interactions Moderate inhibitors of CYP3A4 and P-gp may increase everolimus blood concentrations (e.…
- Everolimus Tablets + Nicardipine— 7.10 Other Possible Interactions Moderate inhibitors of CYP3A4 and P-gp may increase everolimus blood concentrations (e.…