Anastrozole has 5 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Estrogen-Containing Oral Contraceptives, Estrogens, Tamoxifen. Patients taking Anastrozole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Contraindicated
- 4
- Minor
- 1
Contraindicated (4)
- Anastrozole + Estrogen-Containing Oral Contraceptives— Estrogen-containing therapies should not be used with anastrozole as they may diminish its pharmacological action.
- Anastrozole + Estrogens— Estrogen-containing therapies should not be used with anastrozole as they may diminish its pharmacological action.
- Anastrozole + Tamoxifen— Do not use in combination with anastrozole. Co-administration reduced anastrozole plasma concentration by 27% and showed…
- Anastrozole + Tamoxifen Citrate— Tamoxifen should not be administered with anastrozole based on clinical and pharmacokinetic results from adjuvant trial.
Minor (1)
- Anastrozole + Warfarin— Anastrozole did not alter the exposure or anticoagulant activity of warfarin in a study of 16 male volunteers.