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Does Anastrozole Interact with Estrogen Containing Oral Contraceptives?

Anastrozole and Estrogen Containing Oral Contraceptives have a contraindicated drug interaction according to U.S. FDA drug labeling data. Estrogen-containing therapies should not be used with anastrozole as they may diminish its pharmacological action. The mechanism involves may diminish pharmacological action of anastrozole. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Anastrozole Class
Aromatase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Anastrozole and Estrogen Containing Oral Contraceptives occurs because may diminish pharmacological action of anastrozole. Clinically, this means estrogen-containing therapies should not be used with anastrozole as they may diminish its pharmacological action. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Anastrozole and your doctor is considering prescribing Estrogen Containing Oral Contraceptives (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Anastrozole(Anastrozole)+💊 Estrogen Containing Oral Contraceptives

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Aromatase Inhibitor
Drug B class
—
Source
NLP:anastrozole

What this means in plain English

Estrogen-containing therapies should not be used with anastrozole as they may diminish its pharmacological action.

What the FDA label says

"May diminish pharmacological action of anastrozole"

📖 Source: NLP:anastrozole

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.