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Alosetron Hydrochloride

Also known as: Alosetron Hydrochloride

Route: Oral

Check Alosetron Hydrochloride Interactions →

11 interactions on record⛔ Black Box Warning

Alosetron Hydrochloride has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Fluvoxamine, Cimetidine, Clarithromycin. Patients taking Alosetron Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 11
Contraindicated: 1
Moderate: 9

Contraindicated (1)

Alosetron Hydrochloride + Fluvoxamine— Fluvoxamine, a strong CYP1A2 inhibitor, increased alosetron AUC approximately 6-fold and prolonged half-life approximate…

Moderate (9)

Alosetron Hydrochloride + Cimetidine— Moderate CYP1A2 inhibitor. Concomitant administration with alosetron should be avoided unless clinically necessary due t…
Alosetron Hydrochloride + Clarithromycin— Co-administration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, …
Alosetron Hydrochloride + Itraconazole— Co-administration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, …
Alosetron Hydrochloride + Ketoconazole— Ketoconazole, a strong CYP3A4 inhibitor, increased alosetron AUC by 29%. Caution should be used when administered concom…
Alosetron Hydrochloride + Macrolide Antibiotics— Moderate CYP1A2 inhibitors. Concomitant administration with alosetron should be avoided unless clinically necessary due …
Alosetron Hydrochloride + Protease Inhibitors— Strong CYP3A4 inhibitors that should be undertaken with caution due to potential for similar drug interactions with alos…
Alosetron Hydrochloride + Quinolone— Concomitant administration of alosetron and moderate CYP1A2 inhibitors, including quinolone antibiotics and cimetidine, …
Alosetron Hydrochloride + Telithromycin— Co-administration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, …
Alosetron Hydrochloride + Voriconazole— Co-administration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, …

Alosetron Hydrochloride + Fluvoxamine⛔Contraindicated

Fluvoxamine, a strong CYP1A2 inhibitor, increased alosetron AUC approximately 6-fold and prolonged half-life approximately 3-fold. Concomitant use is contraindicated.

Alosetron Hydrochloride + Cimetidine🟡Moderate

Moderate CYP1A2 inhibitor. Concomitant administration with alosetron should be avoided unless clinically necessary due to potential drug interactions.

Alosetron Hydrochloride + Clarithromycin🟡Moderate

Co-administration of alosetron and strong CYP3A4 inhibitors such as clarithromycin, telithromycin, protease inhibitors, voriconazole and itraconazole has not been evaluated but should be undertaken with caution because of similar potential drug interactions.

Alosetron Hydrochloride + Itraconazole🟡Moderate

Alosetron Hydrochloride + Ketoconazole🟡Moderate

Ketoconazole, a strong CYP3A4 inhibitor, increased alosetron AUC by 29%. Caution should be used when administered concomitantly.

Alosetron Hydrochloride + Macrolide Antibiotics🟡Moderate

Moderate CYP1A2 inhibitors. Concomitant administration with alosetron should be avoided unless clinically necessary due to potential drug interactions.

Alosetron Hydrochloride + Protease Inhibitors🟡Moderate

Strong CYP3A4 inhibitors that should be undertaken with caution due to potential for similar drug interactions with alosetron.

Alosetron Hydrochloride + Quinolone🟡Moderate

Concomitant administration of alosetron and moderate CYP1A2 inhibitors, including quinolone antibiotics and cimetidine, has not been evaluated, but should be avoided unless clinically necessary because of similar potential drug interactions.

Alosetron Hydrochloride + Telithromycin🟡Moderate

Alosetron Hydrochloride + Voriconazole🟡Moderate

Alosetron Hydrochloride + Procainamideℹ️Unknown

Although not studied with alosetron, inhibition of N-acetyltransferase may have clinically relevant consequences for drugs such as isoniazid, procainamide and hydralazine.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.