Polymyxins has 11 known drug interactions based on U.S. FDA drug labeling data. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cisatracurium Besylate, Colistimethate, Colistimethate Sodium. Patients taking Polymyxins should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 9
- Moderate
- 2
Major (9)
- Polymyxins + Cisatracurium Besylate— May prolong neuromuscular blockade action of cisatracurium besylate. Use peripheral nerve stimulator and monitor clinica…
- Polymyxins + Colistimethate— Polymyxin interferes with nerve transmission at the neuromuscular junction and should not be given concomitantly except …
- Polymyxins + Colistimethate Sodium— Polymyxin interferes with nerve transmission at the neuromuscular junction and should not be given concomitantly except …
- Polymyxins + Gentamicin Sulfate— Concurrent and/or sequential use should be avoided due to potential neurotoxicity and nephrotoxicity.
- Polymyxins + Pyridostigmine Bromide— Parenteral administration may intensify or produce neuromuscular block and paralysis when used with pyridostigmine.
- Polymyxins + Rocuronium— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Polymyxins + Rocuronium Bromide— May enhance neuromuscular blocking action of rocuronium bromide, causing prolongation of neuromuscular block.
- Polymyxins + Vancomycin Hydrochloride— Potentially nephrotoxic and neurotoxic drug requiring renal function monitoring when used concurrently with vancomycin.
- Polymyxins + Vecuronium Bromide— Polymyxin B may intensify or produce neuromuscular block on its own and can cause unexpected prolongation of vecuronium-…
Moderate (2)
- Polymyxins + Atracurium Besylate— Certain antibiotics, especially polymyxins, may enhance the neuromuscular blocking action of atracurium.
- Polymyxins + Verteporfin For Injection— Could enhance the rate of VISUDYNE uptake by the vascular endothelium, potentially increasing photodynamic effects.