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Diclofenac Potassium 25 Mg

Also known as: Diclofenac Potassium

Route: Oral

Check Diclofenac Potassium 25 Mg Interactions →

5 interactions on record⛔ Black Box Warning

Diclofenac Potassium 25 Mg has 5 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetylsalicylic Acid, Warfarin, Furosemide. Patients taking Diclofenac Potassium 25 Mg should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 2
Moderate: 2

Major (2)

Diclofenac Potassium 25 Mg + Acetylsalicylic Acid— Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding…
Diclofenac Potassium 25 Mg + Warfarin— Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Moderate (2)

Diclofenac Potassium 25 Mg + Furosemide— Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natr…
Diclofenac Potassium 25 Mg + Propranolol— In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence…

Diclofenac Potassium 25 Mg + Acetylsalicylic Acid⚠️Major

Concomitant use associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Diclofenac Potassium 25 Mg + Warfarin⚠️Major

Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Diclofenac Potassium 25 Mg + Furosemide🟡Moderate

Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.

Diclofenac Potassium 25 Mg + Propranolol🟡Moderate

In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the NSAID alone [see Warnings and Precautions ( 5.2 )] Intervention: Concomitant use of Diclofenac Potassium Capsules and analgesic doses of aspirin is not generally recommended because of the increased risk of bleeding [see Warnings and Precautions ( 5.12 )] Diclofenac Potassium Capsules are not a substitute for low dose aspirin for cardiovascular protection ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).

Diclofenac Potassium 25 Mg + Voriconazoleℹ️Unknown

voriconazole) may enhance the exposure and toxicity of diclofenac whereas co- administration with CYP2C9 inducers (e.g.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.