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Potassium Supplements

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68 interactions on record

Potassium Supplements has 68 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 32 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Potassium Bicarbonate, Potassium Chloride, Potassium Chloride For Oral Solution. Patients taking Potassium Supplements should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 68
Contraindicated: 8
Major: 32
Moderate: 28

Contraindicated (8)

Potassium Supplements + Potassium Bicarbonate— Simultaneous administration can produce severe hyperkalemia.
Potassium Supplements + Potassium Chloride— Concomitant use can produce severe hyperkalemia. Avoid concomitant use.
Potassium Supplements + Potassium Chloride For Oral Solution— Use with potassium-sparing diuretics can produce severe hyperkalemia. Avoid concomitant use.
Potassium Supplements + Potassium Phosphate, Monobasic Potassium Phosphate, Dibasic Injection,— Concurrent use increases risk of severe and potentially fatal hyperkalemia. Avoid use; if unavoidable, closely monitor s…
Potassium Supplements + Potassium Phosphates— Increases risk of severe and potentially fatal hyperkalemia. Avoid use; if unavoidable, closely monitor serum potassium.
Potassium Supplements + Potassium Phosphates In Sodium Chloride— Concurrent use increases risk of severe and potentially fatal hyperkalemia. Avoid use; if unavoidable, closely monitor s…
Potassium Supplements + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Increases risk of severe and potentially fatal hyperkalemia, especially with other hyperkalemia risk factors. Avoid conc…
Potassium Supplements + Spironolactone— Concomitant administration can lead to severe hyperkalemia. Potassium supplementation should be discontinued in heart fa…

Major (32)

Potassium Supplements + Amlodipine And Benazepril Hydrochloride— Potassium supplements can increase the risk of hyperkalemia. Frequent monitoring of serum potassium is recommended if co…
Potassium Supplements + Candesartan— Co-administration may result in hyperkalemia. Monitor serum potassium levels in such patients.
Potassium Supplements + Candesartan Cilexetil— Coadministration may result in hyperkalemia. Monitor serum potassium in such patients.
Potassium Supplements + Candesartan Cilexetil And Hydrochlorothiazide— Co-administration may result in hyperkalemia. Monitor serum potassium in such patients.
Potassium Supplements + Captopril And Hydrochlorothiazide— Risk of significant serum potassium elevation. Should only be given for documented hypokalemia and with caution.
Potassium Supplements + Carospir— Concomitant administration with potassium supplementation can lead to severe hyperkalemia. Discontinue in heart failure …
Potassium Supplements + Dextrose And Potassium Chloride— Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly with other hyperkalemia risk fa…
Potassium Supplements + Digoxin— Major contributing factor to digitalis toxicity.
Potassium Supplements + Enalapril— May lead to significant increases in serum potassium.
Potassium Supplements + Enalapril Maleate— Potassium supplements may lead to significant increases in serum potassium when combined with enalapril.
Potassium Supplements + Fosinopril— Can increase risk of hyperkalemia when combined with fosinopril. Should be used with caution and serum potassium monitor…
Potassium Supplements + Fosinopril Sodium— Coadministration may result in hyperkalemia. Monitor serum potassium in such patients.
Potassium Supplements + Irbesartan— Coadministration with drugs that raise serum potassium levels may result in hyperkalemia, sometimes severe. Monitor seru…
Potassium Supplements + Lisinopril And Hydrochlorothiazide Tablets— Potassium supplements may lead to significant hyperkalemia when used with lisinopril which attenuates potassium loss cau…
Potassium Supplements + Losartan Potassium— Concomitant use of losartan and potassium supplements may lead to increases in serum potassium.
Potassium Supplements + Olmesartan Medoxomil— May lead to increases in serum potassium. Monitoring of serum potassium is advisable.
Potassium Supplements + Perindopril Erbumine— Risk of hyperkalemia. Perindopril may increase serum potassium by decreasing aldosterone production.
Potassium Supplements + Potassium Chloride And Sodium Chloride— Increases risk of severe and potentially fatal hyperkalemia, particularly in presence of other risk factors. Avoid use i…
Potassium Supplements + Potassium Chloride Extended-Release— Potassium-sparing diuretics may increase serum potassium levels when used with potassium chloride, potentially leading t…
Potassium Supplements + Potassium Chloride, Dextrose Monohydrate And Sodium Chloride— Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly with other hyperkalemia risk fa…
Potassium Supplements + Potassium Iodide— Concurrent use may result in hyperkalemia and cardiac arrhythmias or cardiac arrest.
Potassium Supplements + Potassium Phosphate, Monobasic— Concurrent use may cause hyperkalemia. Serum potassium levels should be monitored periodically.
Potassium Supplements + Potassium Phosphate, Monobasic And Sodium Phosphate, Monobasic, Anhydrous— May cause hyperkalemia when used with potassium phosphate. Periodic serum potassium monitoring required.
Potassium Supplements + Ramipril— Increases risk of hyperkalemia. Frequent monitoring of serum potassium recommended if concomitant use indicated.
Potassium Supplements + Sodium Chloride, Calcium Chloride, And Potassium Chloride— Concomitant use increases risk of severe and potentially fatal hyperkalemia, especially with other hyperkalemia risk fac…
Potassium Supplements + Sodium Chloride, Sodium Gluconate, Sodium Acetate, Potassium Chloride And Magnesium Chloride— Potassium sparing diuretics increase hyperkalemia risk; avoid use due to potassium content or monitor serum potassium co…
Potassium Supplements + Sodium Phosphate, Dibasic, Anhydrous, Potassium Phosphate, Monobasic, And Sodium Phosphate, Monobasic, Monohydrate— May cause hyperkalemia. Periodic serum potassium level determinations recommended.
Potassium Supplements + Spironolactone And Hydrochlorothiazide— Concomitant administration may lead to severe hyperkalemia.
Potassium Supplements + Trandolapril— Concomitant use with trandolapril increases risk of hyperkalemia and requires caution with appropriate serum potassium m…
Potassium Supplements + Triamterene— Potassium-containing agents given with triamterene promote serum potassium accumulation and may result in hyperkalemia, …
Potassium Supplements + Triamterene And Hydrochlorothiazide— May promote serum potassium accumulation and result in hyperkalemia with triamterene, especially in patients with renal …
Potassium Supplements + Valsartan And Hydrochlorothiazide— May lead to increases in serum potassium and in heart failure patients to increases in serum creatinine when used with v…

Moderate (28)

Potassium Supplements + Aclidinium Bromide And Formoterol Fumarate— ECG changes and hypokalemia from non-potassium-sparing diuretics can be worsened by beta-agonists. Use with caution.
Potassium Supplements + Albuterol Sulfate— ECG changes and hypokalemia from non-potassium-sparing diuretics can be worsened by beta-agonists. Use with caution, esp…
Potassium Supplements + Amlodipine And Valsartan— May lead to increases in serum potassium when combined with valsartan. Monitor serum potassium levels.
Potassium Supplements + Arformoterol Tartrate— Loop or thiazide diuretics can worsen ECG changes and hypokalemia. Caution advised in co-administration.
Potassium Supplements + Benazepril Hydrochloride— Concomitant use may affect potassium levels. Monitor potassium periodically.
Potassium Supplements + Benazepril Hydrochloride And Hydrochlorothiazide— Concomitant use may affect potassium levels. Monitor potassium periodically.
Potassium Supplements + Dexamethasone— Corticosteroids may cause sodium retention with resultant edema and potassium loss when used with potassium-depleting ag…
Potassium Supplements + Drospirenone— May increase serum potassium concentration when used with drospirenone.
Potassium Supplements + Enalapril Maleate And Hydrochlorothiazide— Potassium supplements may lead to significant increases in serum potassium when used concomitantly with enalapril; requi…
Potassium Supplements + Enalaprilat— May lead to significant increases in serum potassium when used with enalaprilat. Use with caution and monitor serum pota…
Potassium Supplements + Fluticasone Propionate And Salmeterol— Electrocardiographic changes and hypokalemia may worsen with concomitant beta-agonists.
Potassium Supplements + Formoterol Fumarate— ECG changes and hypokalemia from these diuretics can be worsened by formoterol, especially at higher doses. Caution advi…
Potassium Supplements + Formoterol Fumarate Dihydrate— ECG changes and hypokalemia from these diuretics can be worsened by formoterol, especially at higher doses. Caution advi…
Potassium Supplements + Fosinopril Sodium And Hydrochlorothiazide— May increase risk of hyperkalemia with fosinopril sodium and hydrochlorothiazide; concomitant use requires caution and f…
Potassium Supplements + Glycopyrrolate And Formoterol Fumarate— ECG changes and hypokalemia from these diuretics can be worsened by formoterol, especially at higher doses. Use with cau…
Potassium Supplements + Ipratropium Bromide And Albuterol Sulfate— β-agonist can acutely worsen ECG changes and hypokalemia induced by diuretics, especially at higher doses. Caution advis…
Potassium Supplements + Moexipril Hydrochloride— Concomitant use with moexipril can increase risk of hyperkalemia. Should be given with caution and patient's serum potas…
Potassium Supplements + Olmesartan Medoxomil And Hydrochlorothiazide— Coadministration may result in hyperkalemia. Monitor serum potassium levels.
Potassium Supplements + Olmesartan Medoxomil-Hydrochlorothiazide— Coadministration with drugs that raise serum potassium levels may result in hyperkalemia. Monitor serum potassium levels…
Potassium Supplements + Olodaterol Respimat Inhalation Spray— ECG changes and hypokalemia from these diuretics can be worsened by olodaterol, especially at high doses. Use with cauti…
Potassium Supplements + Phentermine And Topiramate— Concurrent use may potentiate potassium-wasting action of diuretics. Requires potassium monitoring.
Potassium Supplements + Phentermine And Topiramate Extended-Release— Concurrent use may potentiate the potassium-wasting action of diuretics, requiring monitoring of potassium levels before…
Potassium Supplements + Sacubitril And Valsartan— May lead to increased serum potassium levels. Monitor potassium during concomitant use.
Potassium Supplements + Sodium Lactate, Potassium Chloride, Magnesium Chloride, Monobasic Potassium Phosphate, Sodium Chloride And Dextrose Monohydrate— Avoid use due to potassium content increasing risk of hyperkalemia. If unavoidable, monitor serum potassium concentratio…
Potassium Supplements + Tiotropium Bromide And Olodaterol— Non-potassium sparing diuretics may result in ECG changes and hypokalemia that can be worsened by olodaterol. Caution ad…
Potassium Supplements + Tolvaptan— Concomitant use increases hyperkalemia risk by approximately 1-2%. Serum potassium levels should be monitored.
Potassium Supplements + Trandolapril Tablets— Concomitant use with ACE inhibitors increases risk of hyperkalemia. Use with caution and appropriate monitoring of serum…
Potassium Supplements + Valsartan— May lead to increases in serum potassium and in heart failure patients increases in serum creatinine. Monitor serum pota…

Potassium Supplements + Potassium Bicarbonate⛔Contraindicated

Simultaneous administration can produce severe hyperkalemia.

Potassium Supplements + Potassium Chloride⛔Contraindicated

Concomitant use can produce severe hyperkalemia. Avoid concomitant use.

Potassium Supplements + Potassium Chloride For Oral Solution⛔Contraindicated

Use with potassium-sparing diuretics can produce severe hyperkalemia. Avoid concomitant use.

Potassium Supplements + Potassium Phosphate, Monobasic Potassium Phosphate, Dibasic Injection,⛔Contraindicated

Concurrent use increases risk of severe and potentially fatal hyperkalemia. Avoid use; if unavoidable, closely monitor serum potassium concentrations.

Potassium Supplements + Potassium Phosphates⛔Contraindicated

Increases risk of severe and potentially fatal hyperkalemia. Avoid use; if unavoidable, closely monitor serum potassium.

Potassium Supplements + Potassium Phosphates In Sodium Chloride⛔Contraindicated

Concurrent use increases risk of severe and potentially fatal hyperkalemia. Avoid use; if unavoidable, closely monitor serum potassium concentrations.

Potassium Supplements + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate⛔Contraindicated

Increases risk of severe and potentially fatal hyperkalemia, especially with other hyperkalemia risk factors. Avoid concomitant use.

Potassium Supplements + Spironolactone⛔Contraindicated

Concomitant administration can lead to severe hyperkalemia. Potassium supplementation should be discontinued in heart failure patients starting spironolactone.

Potassium Supplements + Amlodipine And Benazepril Hydrochloride⚠️Major

Potassium supplements can increase the risk of hyperkalemia. Frequent monitoring of serum potassium is recommended if concomitant use is indicated.

Potassium Supplements + Candesartan⚠️Major

Co-administration may result in hyperkalemia. Monitor serum potassium levels in such patients.

Potassium Supplements + Candesartan Cilexetil⚠️Major

Coadministration may result in hyperkalemia. Monitor serum potassium in such patients.

Potassium Supplements + Candesartan Cilexetil And Hydrochlorothiazide⚠️Major

Co-administration may result in hyperkalemia. Monitor serum potassium in such patients.

Potassium Supplements + Captopril And Hydrochlorothiazide⚠️Major

Risk of significant serum potassium elevation. Should only be given for documented hypokalemia and with caution.

Potassium Supplements + Carospir⚠️Major

Concomitant administration with potassium supplementation can lead to severe hyperkalemia. Discontinue in heart failure patients.

Potassium Supplements + Dextrose And Potassium Chloride⚠️Major

Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly with other hyperkalemia risk factors.

Potassium Supplements + Digoxin⚠️Major

Major contributing factor to digitalis toxicity.

Potassium Supplements + Enalapril⚠️Major

May lead to significant increases in serum potassium.

Potassium Supplements + Enalapril Maleate⚠️Major

Potassium supplements may lead to significant increases in serum potassium when combined with enalapril.

Potassium Supplements + Fosinopril⚠️Major

Can increase risk of hyperkalemia when combined with fosinopril. Should be used with caution and serum potassium monitored frequently.

Potassium Supplements + Fosinopril Sodium⚠️Major

Coadministration may result in hyperkalemia. Monitor serum potassium in such patients.

Potassium Supplements + Irbesartan⚠️Major

Coadministration with drugs that raise serum potassium levels may result in hyperkalemia, sometimes severe. Monitor serum potassium in such patients.

Potassium Supplements + Lisinopril And Hydrochlorothiazide Tablets⚠️Major

Potassium supplements may lead to significant hyperkalemia when used with lisinopril which attenuates potassium loss caused by thiazide diuretics.

Potassium Supplements + Losartan Potassium⚠️Major

Concomitant use of losartan and potassium supplements may lead to increases in serum potassium.

Potassium Supplements + Olmesartan Medoxomil⚠️Major

May lead to increases in serum potassium. Monitoring of serum potassium is advisable.

Potassium Supplements + Perindopril Erbumine⚠️Major

Risk of hyperkalemia. Perindopril may increase serum potassium by decreasing aldosterone production.

Potassium Supplements + Potassium Chloride And Sodium Chloride⚠️Major

Increases risk of severe and potentially fatal hyperkalemia, particularly in presence of other risk factors. Avoid use if possible.

Potassium Supplements + Potassium Chloride Extended-Release⚠️Major

Potassium-sparing diuretics may increase serum potassium levels when used with potassium chloride, potentially leading to hyperkalemia.

Potassium Supplements + Potassium Chloride, Dextrose Monohydrate And Sodium Chloride⚠️Major

Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly with other hyperkalemia risk factors.

Potassium Supplements + Potassium Iodide⚠️Major

Concurrent use may result in hyperkalemia and cardiac arrhythmias or cardiac arrest.

Potassium Supplements + Potassium Phosphate, Monobasic⚠️Major

Concurrent use may cause hyperkalemia. Serum potassium levels should be monitored periodically.

Potassium Supplements + Potassium Phosphate, Monobasic And Sodium Phosphate, Monobasic, Anhydrous⚠️Major

May cause hyperkalemia when used with potassium phosphate. Periodic serum potassium monitoring required.

Potassium Supplements + Ramipril⚠️Major

Increases risk of hyperkalemia. Frequent monitoring of serum potassium recommended if concomitant use indicated.

Potassium Supplements + Sodium Chloride, Calcium Chloride, And Potassium Chloride⚠️Major

Concomitant use increases risk of severe and potentially fatal hyperkalemia, especially with other hyperkalemia risk factors. Avoid use; if unavoidable, closely monitor serum potassium.

Potassium Supplements + Sodium Chloride, Sodium Gluconate, Sodium Acetate, Potassium Chloride And Magnesium Chloride⚠️Major

Potassium sparing diuretics increase hyperkalemia risk; avoid use due to potassium content or monitor serum potassium concentrations.

Potassium Supplements + Sodium Phosphate, Dibasic, Anhydrous, Potassium Phosphate, Monobasic, And Sodium Phosphate, Monobasic, Monohydrate⚠️Major

May cause hyperkalemia. Periodic serum potassium level determinations recommended.

Potassium Supplements + Spironolactone And Hydrochlorothiazide⚠️Major

Concomitant administration may lead to severe hyperkalemia.

Potassium Supplements + Trandolapril⚠️Major

Concomitant use with trandolapril increases risk of hyperkalemia and requires caution with appropriate serum potassium monitoring.

Potassium Supplements + Triamterene⚠️Major

Potassium-containing agents given with triamterene promote serum potassium accumulation and may result in hyperkalemia, especially in patients with renal insufficiency.

Potassium Supplements + Triamterene And Hydrochlorothiazide⚠️Major

May promote serum potassium accumulation and result in hyperkalemia with triamterene, especially in patients with renal insufficiency.

Potassium Supplements + Valsartan And Hydrochlorothiazide⚠️Major

May lead to increases in serum potassium and in heart failure patients to increases in serum creatinine when used with valsartan.

Potassium Supplements + Aclidinium Bromide And Formoterol Fumarate🟡Moderate

ECG changes and hypokalemia from non-potassium-sparing diuretics can be worsened by beta-agonists. Use with caution.

Potassium Supplements + Albuterol Sulfate🟡Moderate

ECG changes and hypokalemia from non-potassium-sparing diuretics can be worsened by beta-agonists. Use with caution, especially at higher albuterol doses.

Potassium Supplements + Amlodipine And Valsartan🟡Moderate

May lead to increases in serum potassium when combined with valsartan. Monitor serum potassium levels.

Potassium Supplements + Arformoterol Tartrate🟡Moderate

Loop or thiazide diuretics can worsen ECG changes and hypokalemia. Caution advised in co-administration.

Potassium Supplements + Benazepril Hydrochloride🟡Moderate

Concomitant use may affect potassium levels. Monitor potassium periodically.

Potassium Supplements + Benazepril Hydrochloride And Hydrochlorothiazide🟡Moderate

Concomitant use may affect potassium levels. Monitor potassium periodically.

Potassium Supplements + Dexamethasone🟡Moderate

Corticosteroids may cause sodium retention with resultant edema and potassium loss when used with potassium-depleting agents. Closely monitor potassium levels.

Potassium Supplements + Drospirenone🟡Moderate

May increase serum potassium concentration when used with drospirenone.

Potassium Supplements + Enalapril Maleate And Hydrochlorothiazide🟡Moderate

Potassium supplements may lead to significant increases in serum potassium when used concomitantly with enalapril; requires frequent monitoring.

Potassium Supplements + Enalaprilat🟡Moderate

May lead to significant increases in serum potassium when used with enalaprilat. Use with caution and monitor serum potassium frequently.

Potassium Supplements + Fluticasone Propionate And Salmeterol🟡Moderate

Electrocardiographic changes and hypokalemia may worsen with concomitant beta-agonists.

Potassium Supplements + Formoterol Fumarate🟡Moderate

ECG changes and hypokalemia from these diuretics can be worsened by formoterol, especially at higher doses. Caution advised.

Potassium Supplements + Formoterol Fumarate Dihydrate🟡Moderate

ECG changes and hypokalemia from these diuretics can be worsened by formoterol, especially at higher doses. Caution advised.

Potassium Supplements + Fosinopril Sodium And Hydrochlorothiazide🟡Moderate

May increase risk of hyperkalemia with fosinopril sodium and hydrochlorothiazide; concomitant use requires caution and frequent serum potassium monitoring.

Potassium Supplements + Glycopyrrolate And Formoterol Fumarate🟡Moderate

ECG changes and hypokalemia from these diuretics can be worsened by formoterol, especially at higher doses. Use with caution.

Potassium Supplements + Ipratropium Bromide And Albuterol Sulfate🟡Moderate

β-agonist can acutely worsen ECG changes and hypokalemia induced by diuretics, especially at higher doses. Caution advised.

Potassium Supplements + Moexipril Hydrochloride🟡Moderate

Concomitant use with moexipril can increase risk of hyperkalemia. Should be given with caution and patient's serum potassium should be monitored.

Potassium Supplements + Olmesartan Medoxomil And Hydrochlorothiazide🟡Moderate

Coadministration may result in hyperkalemia. Monitor serum potassium levels.

Potassium Supplements + Olmesartan Medoxomil-Hydrochlorothiazide🟡Moderate

Coadministration with drugs that raise serum potassium levels may result in hyperkalemia. Monitor serum potassium levels.

Potassium Supplements + Olodaterol Respimat Inhalation Spray🟡Moderate

ECG changes and hypokalemia from these diuretics can be worsened by olodaterol, especially at high doses. Use with caution.

Potassium Supplements + Phentermine And Topiramate🟡Moderate

Concurrent use may potentiate potassium-wasting action of diuretics. Requires potassium monitoring.

Potassium Supplements + Phentermine And Topiramate Extended-Release🟡Moderate

Concurrent use may potentiate the potassium-wasting action of diuretics, requiring monitoring of potassium levels before and during treatment.

Potassium Supplements + Sacubitril And Valsartan🟡Moderate

May lead to increased serum potassium levels. Monitor potassium during concomitant use.

Potassium Supplements + Sodium Lactate, Potassium Chloride, Magnesium Chloride, Monobasic Potassium Phosphate, Sodium Chloride And Dextrose Monohydrate🟡Moderate

Avoid use due to potassium content increasing risk of hyperkalemia. If unavoidable, monitor serum potassium concentrations.

Potassium Supplements + Tiotropium Bromide And Olodaterol🟡Moderate

Non-potassium sparing diuretics may result in ECG changes and hypokalemia that can be worsened by olodaterol. Caution advised in co-administration.

Potassium Supplements + Tolvaptan🟡Moderate

Concomitant use increases hyperkalemia risk by approximately 1-2%. Serum potassium levels should be monitored.

Potassium Supplements + Trandolapril Tablets🟡Moderate

Concomitant use with ACE inhibitors increases risk of hyperkalemia. Use with caution and appropriate monitoring of serum potassium.

Potassium Supplements + Valsartan🟡Moderate

May lead to increases in serum potassium and in heart failure patients increases in serum creatinine. Monitor serum potassium if coadministration is necessary.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.