Potassium Chloride has 19 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aldosterone, Amiloride, Eplerenone. Patients taking Potassium Chloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 19
- Contraindicated
- 8
- Major
- 7
- Moderate
- 4
Contraindicated (8)
- Potassium Chloride + Aldosterone— 7 DRUG INTERACTIONS Triamterene and amiloride: Concomitant use is contraindicated (7.1) Renin-angiotensin-aldosterone in…
- Potassium Chloride + Amiloride— Concomitant use can produce severe hyperkalemia. Contraindicated.
- Potassium Chloride + Eplerenone— Concomitant use can produce severe hyperkalemia. Avoid concomitant use.
- Potassium Chloride + Glycopyrrolate— Solid dosage forms of potassium chloride are contraindicated due to arrested or delayed passage through GI tract with gl…
- Potassium Chloride + Glycopyrrolate Oral Solution— Solid dosage forms of potassium chloride are contraindicated. Passage through GI tract may be arrested or delayed with g…
- Potassium Chloride + Potassium Supplements— Concomitant use can produce severe hyperkalemia. Avoid concomitant use.
- Potassium Chloride + Spironolactone— Concomitant use can produce severe hyperkalemia. Avoid concomitant use.
- Potassium Chloride + Triamterene— Concomitant use can produce severe hyperkalemia. Contraindicated.
Major (7)
- Potassium Chloride + Aliskiren— RAAS inhibitor that produces potassium retention by inhibiting aldosterone production. Monitor potassium levels.
- Potassium Chloride + Angiotensin Ii— Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly in presence of other hyperkalem…
- Potassium Chloride + Aspirin— Monitor for hyperkalemia. NSAIDs may produce potassium retention by reducing renal prostaglandin E synthesis and impairi…
- Potassium Chloride + Cyclosporine— Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly in presence of other hyperkalem…
- Potassium Chloride + Mao Inhibitors— Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly in presence of other hyperkalem…
- Potassium Chloride + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— NSAIDs may produce potassium retention by reducing renal prostaglandin E synthesis and impairing the renin-angiotensin s…
- Potassium Chloride + Tacrolimus— Concurrent use increases risk of severe and potentially fatal hyperkalemia, particularly in presence of other hyperkalem…
Moderate (4)
- Potassium Chloride + Diuretics— Concomitant use may increase risk of hyponatremia. Monitor serum sodium concentrations if use cannot be avoided.
- Potassium Chloride + Hyoscyamine Sulfate— Absorption of potassium chloride may be decreased during concurrent use due to decreased gastrointestinal motility and d…
- Potassium Chloride + Ibuprofen— May increase serum potassium levels. Closely monitor potassium levels in patients receiving concomitant NSAIDs.
- Potassium Chloride + Prenatal Multivitamin Tablet And Combination Omega-3 Softgel/Mineral Capsule— May decrease the absorption of vitamin B12.