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Insulin Lispro

Also known as: Insulin Lispro, Insulin Lispro Junior Kwikpen, Insulin Lispro Kwikpen

Insulin Analog

Route: Intravenous, Subcutaneous

37 interactions on record

Insulin Lispro has 37 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Disopyramide, Fluoxetine, Octreotide. Patients taking Insulin Lispro should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 37
Major: 5
Moderate: 30

Major (5)

Insulin Lispro + Disopyramide— May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Fluoxetine— May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Octreotide— Somatostatin analog that may increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring require…
Insulin Lispro + Pentoxifylline— May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Pramlintide— May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.

Moderate (30)

Insulin Lispro + Albuterol— Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring …
Insulin Lispro + Alcohol— May increase or decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Angiotensin Ii— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Lispro + Clonidine— May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia; increased glucose m…
Insulin Lispro + Clozapine— Atypical antipsychotic that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring…
Insulin Lispro + Corticosteroids— May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be req…
Insulin Lispro + Danazol— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Diuretics— May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be req…
Insulin Lispro + Epinephrine— Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring …
Insulin Lispro + Estrogens— May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be req…
Insulin Lispro + Fibrates— May increase the risk of hypoglycemia. Dose adjustment and increased frequency of glucose monitoring may be required.
Insulin Lispro + Glucagon— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Guanethidine— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.
Insulin Lispro + Isoniazid— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Lithium— May increase or decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Macrolide Antibiotics— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Lispro + Mao Inhibitors— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Lispro + Monoamine Oxidase Inhibitors (Maois)— May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.
Insulin Lispro + Niacin— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Nonselective Beta-Adrenergic Antagonists— May increase or decrease blood glucose lowering effect and may blunt signs and symptoms of hypoglycemia. Increased gluco…
Insulin Lispro + Olanzapine— Atypical antipsychotic that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring…
Insulin Lispro + Oral Contraceptives— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Lispro + Pentamidine— May cause hypoglycemia followed sometimes by hyperglycemia; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Phenothiazines— May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be req…
Insulin Lispro + Protease Inhibitors— May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.
Insulin Lispro + Reserpine— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.
Insulin Lispro + Salicylates— May increase the risk of hypoglycemia. Dose adjustment and increased frequency of glucose monitoring may be required.
Insulin Lispro + Somatropin— May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.
Insulin Lispro + Terbutaline— Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring …
Insulin Lispro + Thyroid Hormones— May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be req…

Insulin Lispro + Disopyramide⚠️Major

May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Fluoxetine⚠️Major

May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Octreotide⚠️Major

Somatostatin analog that may increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Pentoxifylline⚠️Major

May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Pramlintide⚠️Major

May increase the risk of hypoglycemia; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Albuterol🟡Moderate

Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Alcohol🟡Moderate

May increase or decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Angiotensin Ii🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Lispro + Clonidine🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs/symptoms of hypoglycemia; increased glucose monitoring required.

Insulin Lispro + Clozapine🟡Moderate

Atypical antipsychotic that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Corticosteroids🟡Moderate

May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be required.

Insulin Lispro + Danazol🟡Moderate

May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Diuretics🟡Moderate

May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be required.

Insulin Lispro + Epinephrine🟡Moderate

Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Estrogens🟡Moderate

May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be required.

Insulin Lispro + Fibrates🟡Moderate

May increase the risk of hypoglycemia. Dose adjustment and increased frequency of glucose monitoring may be required.

Insulin Lispro + Glucagon🟡Moderate

May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Guanethidine🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.

Insulin Lispro + Isoniazid🟡Moderate

May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Lithium🟡Moderate

May increase or decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Macrolide Antibiotics🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Lispro + Mao Inhibitors🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Lispro + Monoamine Oxidase Inhibitors (Maois)🟡Moderate

May increase risk of hypoglycemia. Dose adjustment and increased glucose monitoring may be required.

Insulin Lispro + Niacin🟡Moderate

May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Nonselective Beta-Adrenergic Antagonists🟡Moderate

May increase or decrease blood glucose lowering effect and may blunt signs and symptoms of hypoglycemia. Increased glucose monitoring required.

Insulin Lispro + Olanzapine🟡Moderate

Atypical antipsychotic that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Oral Contraceptives🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Lispro + Pentamidine🟡Moderate

May cause hypoglycemia followed sometimes by hyperglycemia; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Phenothiazines🟡Moderate

May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be required.

Insulin Lispro + Protease Inhibitors🟡Moderate

May decrease blood glucose lowering effect. Dose adjustment and increased glucose monitoring may be required.

Insulin Lispro + Reserpine🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring required.

Insulin Lispro + Salicylates🟡Moderate

May increase the risk of hypoglycemia. Dose adjustment and increased frequency of glucose monitoring may be required.

Insulin Lispro + Somatropin🟡Moderate

May decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Terbutaline🟡Moderate

Sympathomimetic agent that may decrease blood glucose lowering effect; dose adjustment and increased glucose monitoring required.

Insulin Lispro + Thyroid Hormones🟡Moderate

May decrease the blood glucose lowering effect. Dose adjustment and increased frequency of glucose monitoring may be required.

Insulin Lispro + Acetazolamideℹ️Unknown

Table 2: Clinically Significant Drug Interactions with ADMELOG Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics ( 7 ).

Insulin Lispro + Somatostatinℹ️Unknown

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.