Metformin Er 500 Mg has 21 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Cimetidine, Dichlorphenamide. Patients taking Metformin Er 500 Mg should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Major
- 8
- Moderate
- 13
Major (8)
- Metformin Er 500 Mg + Acetazolamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis with metformin.
- Metformin Er 500 Mg + Cimetidine— Reduces metformin clearance, increasing systemic exposure and risk of lactic acidosis.
- Metformin Er 500 Mg + Dichlorphenamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis with metformin.
- Metformin Er 500 Mg + Dolutegravir— OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk of lactic acidosis.
- Metformin Er 500 Mg + Ranolazine— OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk of lactic acidosis.
- Metformin Er 500 Mg + Topiramate— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis with metformin.
- Metformin Er 500 Mg + Vandetanib— OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk of lactic acidosis.
- Metformin Er 500 Mg + Zonisamide— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis with metformin.
Moderate (13)
- Metformin Er 500 Mg + Alcohol— Potentiates the effect of metformin on lactate metabolism. Warn patients against excessive alcohol intake.
- Metformin Er 500 Mg + Andthiazide— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Calcium Channel Blockers— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Corticosteroids— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Estrogens— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Insulin Human— Coadministration with metformin may increase risk of hypoglycemia. Patient may require lower insulin doses.
- Metformin Er 500 Mg + Isoniazid— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Niacin— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Oral Contraceptives— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Phenothiazines— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Phenytoin— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
- Metformin Er 500 Mg + Sulfonylurea— Insulin secretagogue that with metformin may increase risk of hypoglycemia. Patient may require lower doses of insulin s…
- Metformin Er 500 Mg + Thyroid— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…