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Guanfacine Er

Also known as: Guanfacine Er

Route: Oral

4 interactions on record

Guanfacine Er has 4 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Efavirenz, Fluconazole, Ketoconazole. Patients taking Guanfacine Er should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 4
Moderate: 4

Moderate (4)

Guanfacine Er + Efavirenz— Moderate CYP3A4 inducer that significantly decreases guanfacine plasma concentrations. Consider dose increase.
Guanfacine Er + Fluconazole— Table 14: Clinically Important Drug Interactions: Effect of other Drugs on Guanfacine Concomitant Drug Name or Drug Clas…
Guanfacine Er + Ketoconazole— Table 14: Clinically Important Drug Interactions: Effect of other Drugs on Guanfacine Concomitant Drug Name or Drug Clas…
Guanfacine Er + Rifampin— Strong CYP3A4 inducer that significantly decreases guanfacine plasma concentrations. Consider dose increase.

Guanfacine Er + Efavirenz🟡Moderate

Moderate CYP3A4 inducer that significantly decreases guanfacine plasma concentrations. Consider dose increase.

Guanfacine Er + Fluconazole🟡Moderate

Table 14: Clinically Important Drug Interactions: Effect of other Drugs on Guanfacine Concomitant Drug Name or Drug Class Clinical Rationale and Magnitude of Drug Interaction Clinical Recommendation Strong and moderate CYP3A4 inhibitors, e.g., ketoconazole, fluconazole Guanfacine is primarily metabolized by CYP3A4 and its plasma concentrations can be significantly affected resulting in an increase in exposure Consider dose reduction [see Dosage and administration (2.7)] Strong and moderate CYP3A4 inducers, e.g., rifampin, efavirenz Guanfacine is primarily metabolized by CYP3A4 and its plasma concentrations can be significantly affected resulting in a decrease in exposure Consider dose increase [see Dosage and administration (2.7)]

Guanfacine Er + Ketoconazole🟡Moderate

Guanfacine Er + Rifampin🟡Moderate

Strong CYP3A4 inducer that significantly decreases guanfacine plasma concentrations. Consider dose increase.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.