Praziquantel has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Rifampin, Albendazole, Chloroquine Phosphate. Patients taking Praziquantel should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 1
- Moderate
- 11
Contraindicated (1)
- Praziquantel + Rifampin— Strong CYP 3A inducer that decreases praziquantel AUC and Cmax, reducing efficacy of Biltricide.
Moderate (11)
- Praziquantel + Albendazole— In the fed state, praziquantel increased mean maximum plasma concentration and area under the curve of albendazole sulfo…
- Praziquantel + Chloroquine Phosphate— Chloroquine reduces the bioavailability of praziquantel.
- Praziquantel + Cimetidine— CYP450 inhibitor that may increase plasma concentrations of praziquantel.
- Praziquantel + Efavirenz— Moderate CYP 3A inducer that decreases praziquantel AUC and Cmax. Should be avoided unless benefit outweighs risks.
- Praziquantel + Erythromycin— Concomitant administration of a Moderate CYP 3A inducer, such as efavirenz, should be avoided unless the benefit outweig…
- Praziquantel + Grapefruit Juice— Reported to produce 1.6-fold increase in Cmax and 1.9-fold increase in AUC of praziquantel. Safety effects not systemati…
- Praziquantel + Hydroxychloroquine— Chloroquine reduces praziquantel bioavailability; similar interaction with hydroxychloroquine cannot be ruled out.
- Praziquantel + Hydroxychloroquine Sulfate— Chloroquine has been reported to reduce the bioavailability of praziquantel; cannot be ruled out for hydroxychloroquine.
- Praziquantel + Itraconazole— Concomitant administration of a Moderate CYP 3A inducer, such as efavirenz, should be avoided unless the benefit outweig…
- Praziquantel + Ketoconazole— Concomitant administration of a Moderate CYP 3A inducer, such as efavirenz, should be avoided unless the benefit outweig…
- Praziquantel + Ritonavir— Concomitant administration of a Moderate CYP 3A inducer, such as efavirenz, should be avoided unless the benefit outweig…