Prilocaine has 27 known drug interactions based on U.S. FDA drug labeling data. 22 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Articaine Hydrochloride And Epinephrine, Articaine Hydrochloride And Epinephrine Bitartrate, Bupivacaine Hydrochloride. Patients taking Prilocaine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 27
- Major
- 22
- Moderate
- 5
Major (22)
- Prilocaine + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed with articaine and other local anesthetics.
- Prilocaine + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
- Prilocaine + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Prilocaine + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Prilocaine + Lidocaine 5%— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
- Prilocaine + Lidocaine And Capsaicin— Local anesthetic that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
- Prilocaine + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
- Prilocaine + Lidocaine Hydrochloride And Epinephrine Bitartrate— Local anesthetic associated with increased methemoglobinemia risk when used concurrently.
- Prilocaine + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetics are concurrently used.
- Prilocaine + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
- Prilocaine + Lidocaine Patch 5%— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Prilocaine + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
- Prilocaine + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to local anesthetics.
- Prilocaine + Lidothol Patch— Increased risk of methemoglobinemia with concurrent use of multiple local anesthetics.
- Prilocaine + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to local anesthetics. Monitor for signs of methemoglobinem…
- Prilocaine + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
- Prilocaine + Nitric Oxide— May increase the risk of developing methemoglobinemia when used with nitric oxide.
- Prilocaine + Ropivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to ropivacaine.
- Prilocaine + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed. Local anesthetic with potential for methemoglobin formati…
- Prilocaine + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
- Prilocaine + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch; total amount absorbed from all formulatio…
- Prilocaine + Ulspira— May increase risk of developing methemoglobinemia when used with ULSPIRA.
Moderate (5)
- Prilocaine + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Prilocaine + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
- Prilocaine + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Additive toxic effects and increased methemoglobinemia risk when used with ropivacaine.
- Prilocaine + Lidocaine And Tetracaine— Local anesthetic that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
- Prilocaine + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when concurrently exposed with local anesthetics (procaine is a component of this dr…