Primaquine has 35 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 29 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Primaquine Phosphate, Articaine Hydrochloride And Epinephrine, Articaine Hydrochloride And Epinephrine Bitartrate. Patients taking Primaquine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 35
Contraindicated: 1
Major: 29
Moderate: 5

Contraindicated (1)

Primaquine + Primaquine Phosphate— Increased toxicity was seen when quinacrine was used with pamaquine, another 8-aminoquinoline.

Major (29)

Primaquine + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed to articaine.
Primaquine + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this antimalarial.
Primaquine + Benzocaine, Butamben, And Tetracaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to this antimalarial oxidizing agent with local anesthetic…
Primaquine + Bupivacaine And Meloxicam— Increased risk of methemoglobinemia when local anesthetics are used concomitantly with antimalarials.
Primaquine + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
Primaquine + Dapsone— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
Primaquine + Dapsone Gel, 5%— Concomitant use may increase risk of developing methemoglobinemia. Monitor closely.
Primaquine + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Antimalarial associated with increased methemoglobinemia risk when used with ropivacaine.
Primaquine + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
Primaquine + Lidocaine 5%— Antimalarial that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Primaquine + Lidocaine And Capsaicin— Antimalarial drug that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
Primaquine + Lidocaine And Prilocaine— Antimalarial; increased risk of methemoglobinemia when concurrently exposed.
Primaquine + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Primaquine + Lidocaine Hydrochloride And Epinephrine Bitartrate— Antimalarial associated with increased methemoglobinemia risk when used concurrently.
Primaquine + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to antimalarials.
Primaquine + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
Primaquine + Lidocaine Patch 5%— Increased risk of methemoglobinemia; antimalarials associated with methemoglobinemia when used with local anesthetics.
Primaquine + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
Primaquine + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to antimalarials.
Primaquine + Lidothol Patch— Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to antimalarials.
Primaquine + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antimalarials.
Primaquine + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
Primaquine + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when penicillin is concurrently administered with primaquine (an antimalarial).
Primaquine + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to primaquine.
Primaquine + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
Primaquine + Ropivacaine Hydrochloride— Increased risk of developing methemoglobinemia when concurrently exposed to primaquine.
Primaquine + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed.
Primaquine + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
Primaquine + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch.

Moderate (5)

Primaquine + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
Primaquine + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
Primaquine + Bupivacaine Hydrochloride With Dextrose— Increased risk of developing methemoglobinemia when concurrently exposed.
Primaquine + Lidocaine And Tetracaine— Antimalarial drug that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
Primaquine + Marcaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antimalarials with bupivacaine.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.