Propantheline has 3 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Cefpodoxime Proxetil, Clonazepam, Digoxin. Patients taking Propantheline should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 3
- Moderate
- 3
Moderate (3)
- Propantheline + Cefpodoxime Proxetil— Delays peak plasma levels with 47% increase in Tmax, but does not affect extent of absorption.
- Propantheline + Clonazepam— Anticholinergic agent decreases clonazepam AUC by 10% and Cmax by 20% when given with clonazepam orally disintegrating t…
- Propantheline + Digoxin— Increases digoxin serum concentration by 24% and AUC by 24%. Requires monitoring and dose adjustment.