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Levoleucovorin

Also known as: Khapzory

Route: Intravenous

6 interactions on record

Levoleucovorin has 6 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fluorouracil, Sulfamethoxazole And Trimethoprim, Phenobarbital. Patients taking Levoleucovorin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Major: 2
Moderate: 3

Major (2)

Levoleucovorin + Fluorouracil— Levoleucovorin increases toxicity of fluorouracil. Do not initiate therapy until gastrointestinal toxicity symptoms reso…
Levoleucovorin + Sulfamethoxazole And Trimethoprim— Concomitant use with levoleucovorin for acute treatment of Pneumocystis jiroveci pneumonia in HIV patients was associate…

Moderate (3)

Levoleucovorin + Phenobarbital— Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency in susceptible children. …
Levoleucovorin + Phenytoin— Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency in susceptible children. …
Levoleucovorin + Primidone— Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency in susceptible children. …

Levoleucovorin + Fluorouracil⚠️Major

Levoleucovorin increases toxicity of fluorouracil. Do not initiate therapy until gastrointestinal toxicity symptoms resolve. Monitor for diarrhea as rapid deterioration leading to death can occur.

Levoleucovorin + Sulfamethoxazole And Trimethoprim⚠️Major

Concomitant use with levoleucovorin for acute treatment of Pneumocystis jiroveci pneumonia in HIV patients was associated with increased treatment failure and morbidity.

Levoleucovorin + Phenobarbital🟡Moderate

Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency in susceptible children. Monitor patients taking levoleucovorin with this drug.

Levoleucovorin + Phenytoin🟡Moderate

Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency in susceptible children. Monitor patients taking levoleucovorin with this drug.

Levoleucovorin + Primidone🟡Moderate

Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency in susceptible children. Monitor patients taking levoleucovorin with this drug.

Levoleucovorin + Sulfamethoxazoleℹ️Unknown

Trimethoprim-Sulfamethoxazole The concomitant use of d,l -leucovorin with trimethoprim-sulfamethoxazole for the acute treatment of Pneumocystis jiroveci pneumonia in patients with HIV infection was associated with increased rates of treatment failure and morbidity in a placebo-controlled study [see Warnings and Precautions (5.3) ] .

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.