Propoxyphene

10 interactions on record

Propoxyphene has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Safinamide Mesylate, Alprazolam, Alprazolam Odt C-Iv. Patients taking Propoxyphene should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Contraindicated: 1
Moderate: 7
Minor: 2

Contraindicated (1)

Propoxyphene + Safinamide Mesylate— Serious, sometimes fatal reactions reported with concomitant use of opioid drugs and MAOIs, including selective MAO-B in…

Moderate (7)

Propoxyphene + Alprazolam— Decreased alprazolam maximum plasma concentration by 6%, decreased clearance by 38%, and increased half-life by 58%.
Propoxyphene + Alprazolam Odt C-Iv— Coadministration decreased alprazolam maximum plasma concentration by 6%, decreased clearance by 38%, and increased half…
Propoxyphene + Carbamazepine— CYP3A4 inhibitor that increases carbamazepine plasma levels; close monitoring and dosage adjustment may be required.
Propoxyphene + Glimepiride— May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.
Propoxyphene + Glipizide— May increase glucose-lowering effect of glipizide and susceptibility to hypoglycemia; monitor closely.
Propoxyphene + Pioglitazone And Glimepiride— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia. Close monitoring require…
Propoxyphene + Repaglinide— May increase risk of hypoglycemia. Repaglinide dose reductions and increased glucose monitoring may be required.

Minor (2)

Propoxyphene + Prazosin— Prazosin has been administered without adverse drug interaction with propoxyphene in limited clinical experience.
Propoxyphene + Prazosin Hydrochloride— Administered without adverse drug interaction in limited clinical experience.

Propoxyphene + Safinamide Mesylate⛔Contraindicated

Serious, sometimes fatal reactions reported with concomitant use of opioid drugs and MAOIs, including selective MAO-B inhibitors.

Propoxyphene + Alprazolam🟡Moderate

Decreased alprazolam maximum plasma concentration by 6%, decreased clearance by 38%, and increased half-life by 58%.

Propoxyphene + Alprazolam Odt C-Iv🟡Moderate

Coadministration decreased alprazolam maximum plasma concentration by 6%, decreased clearance by 38%, and increased half-life by 58%.

Propoxyphene + Carbamazepine🟡Moderate

CYP3A4 inhibitor that increases carbamazepine plasma levels; close monitoring and dosage adjustment may be required.

Propoxyphene + Glimepiride🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia.

Propoxyphene + Glipizide🟡Moderate

May increase glucose-lowering effect of glipizide and susceptibility to hypoglycemia; monitor closely.

Propoxyphene + Pioglitazone And Glimepiride🟡Moderate

May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia. Close monitoring required.

Propoxyphene + Repaglinide🟡Moderate

May increase risk of hypoglycemia. Repaglinide dose reductions and increased glucose monitoring may be required.

Propoxyphene + Prazosin🟢Minor

Prazosin has been administered without adverse drug interaction with propoxyphene in limited clinical experience.

Propoxyphene + Prazosin Hydrochloride🟢Minor

Administered without adverse drug interaction in limited clinical experience.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.