Rizatriptan has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dihydroergotamine, Ergotamine, Mao Inhibitors. Patients taking Rizatriptan should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Contraindicated
- 6
- Major
- 1
- Moderate
- 2
Contraindicated (6)
- Rizatriptan + Dihydroergotamine— Dihydroergotamine causes prolonged vasospastic reactions with additive effects. Use within 24 hours is contraindicated.
- Rizatriptan + Ergotamine— Ergotamine-containing drugs cause prolonged vasospastic reactions with additive effects. Use within 24 hours is contrain…
- Rizatriptan + Mao Inhibitors— Rizatriptan is contraindicated in patients taking MAO-A inhibitors due to increased systemic exposure.
- Rizatriptan + Methysergide— Methysergide causes prolonged vasospastic reactions with additive effects. Use within 24 hours is contraindicated.
- Rizatriptan + Monoamine Oxidase Inhibitors (Maois)— Rizatriptan is contraindicated in patients taking MAO-A inhibitors due to increased systemic exposure of rizatriptan and…
- Rizatriptan + Other 5-Ht1 Agonists— Co-administration within 24 hours is contraindicated due to additive vasospastic effects.
Major (1)
- Rizatriptan + Selective Serotonin Reuptake Inhibitors (Ssri)— SSRIs co-administered with rizatriptan have been reported to cause serotonin syndrome.
Moderate (2)
- Rizatriptan + Propranolol— Propranolol increases plasma AUC of rizatriptan by 70%, requiring dose adjustment of rizatriptan.
- Rizatriptan + Propranolol Hydrochloride— CYP1A2 substrate/inhibitor that may increase propranolol levels; also propranolol increases rizatriptan AUC by 67% and C…