Protriptyline has 6 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amphetamine, Amphetamine Sulfate, Dextroamphetamine. Patients taking Protriptyline should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Major
- 6
Major (6)
- Protriptyline + Amphetamine— Tricyclic antidepressant causing striking sustained increases in d-amphetamine brain concentration with potentiated card…
- Protriptyline + Amphetamine Sulfate— Tricyclic antidepressant that causes striking and sustained increases in brain d-amphetamine concentration with potentia…
- Protriptyline + Dextroamphetamine— Amphetamines enhance activity of protriptyline causing striking and sustained effects.
- Protriptyline + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Tricyclic antidepressant may enhance activity causing striking sustained increases in d-amphetamine concentration and po…
- Protriptyline + Dextroamphetamine Sulfate— Tricyclic antidepressant causing striking sustained increases in brain d-amphetamine concentration and potentiated cardi…
- Protriptyline + Norepinephrine Bitartrate— Co-administration can cause severe, prolonged hypertension. Monitor for hypertension if norepinephrine bitartrate cannot…