Pseudoephedrine has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Tranylcypromine Sulfate, Midodrine Hydrochloride, Iobenguane I-123. Patients taking Pseudoephedrine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 1
- Major
- 1
- Moderate
- 2
- Minor
- 2
Contraindicated (1)
- Pseudoephedrine + Tranylcypromine Sulfate— Sympathomimetic vasopressor contraindicated; avoid or emergency use only with tranylcypromine discontinuation and monito…
Major (1)
- Pseudoephedrine + Midodrine Hydrochloride— Increases risk of hypertension when used concomitantly with midodrine. Avoid concomitant use or monitor blood pressure c…
Moderate (2)
- Pseudoephedrine + Iobenguane I-123— Sympathomimetic amine that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Pseudoephedrine + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Renal clearance of alkaline sympathomimetics like pseudoephedrine may be decreased due to alkalinizing action of lactate…
Minor (2)
- Pseudoephedrine + Cetirizine Hydrochloride— No clinically significant interaction found.
- Pseudoephedrine + Levocetirizine Dihydrochloride— Pharmacokinetic interaction study with racemic cetirizine showed no interaction with pseudoephedrine.