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Pyrazinamide

Antimycobacterial

Route: Oral

6 interactions on record

Pyrazinamide has 6 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Probenecid, Probenecid And Colchicine, Salicylic Acid. Patients taking Pyrazinamide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Moderate: 4

Moderate (4)

Pyrazinamide + Probenecid— Pyrazinamide antagonizes the uricosuric action of probenecid.
Pyrazinamide + Probenecid And Colchicine— Pyrazinamide antagonizes the uricosuric action of probenecid.
Pyrazinamide + Salicylic Acid— Salicylate inhibits pyrazinamide-induced hyperuricemia.
Pyrazinamide + Salicylic Acid 10%— Salicylate inhibits pyrazinamide-induced hyperuricemia.

Pyrazinamide + Probenecid🟡Moderate

Pyrazinamide antagonizes the uricosuric action of probenecid.

Pyrazinamide + Probenecid And Colchicine🟡Moderate

Pyrazinamide antagonizes the uricosuric action of probenecid.

Pyrazinamide + Salicylic Acid🟡Moderate

Salicylate inhibits pyrazinamide-induced hyperuricemia.

Pyrazinamide + Salicylic Acid 10%🟡Moderate

Salicylate inhibits pyrazinamide-induced hyperuricemia.

Pyrazinamide + Bedaquiline Fumarateℹ️Unknown

7.2 Other Antimicrobial Medications No dose adjustment of isoniazid or pyrazinamide is required during coadministration with SIRTURO. In a placebo-controlled clinical trial in adult patients, no major impact of coadministration of SIRTURO on the pharmacokinetics of ethambutol, kanamycin, pyrazinamide, ofloxacin or cycloserine was observed.

Pyrazinamide + Rifampinℹ️Unknown

Decrease exposure Selective 5-HT3 Receptor Antagonists Ondansetron Decrease exposure Statins Metabolized by CYP3A4 Simvastatin Decrease exposure Thiazolidinediones Rosiglitazone Decrease AUC by 66% Tricyclic Antidepressants Nortriptyline A tuberculosis treatment regimen including rifampin (600 mg/day), isoniazid (300 mg/day), pyrazinamide (500 mg 3× per day), and pyridoxine (25 mg) was associated with higher than expected doses of nortriptyline were required to obtain a therapeutic drug level.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.