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Codeine Sulfate

Also known as: Codeine Sulfate

Route: Oral

8 interactions on record⛔ Black Box Warning

Codeine Sulfate has 8 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Erythromycin, Ketoconazole. Patients taking Codeine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 8
Major: 6
Minor: 2

Major (6)

Codeine Sulfate + Carbamazepine— CYP3A4 inducer that decreases codeine and morphine levels, resulting in reduced efficacy or withdrawal syndrome in depen…
Codeine Sulfate + Erythromycin— CYP3A4 inhibitor that increases codeine plasma concentrations and morphine levels, potentially causing fatal respiratory…
Codeine Sulfate + Ketoconazole— Azole antifungal CYP3A4 inhibitor that increases codeine and morphine levels, potentially causing fatal respiratory depr…
Codeine Sulfate + Phenytoin— CYP3A4 inducer that decreases codeine and morphine levels, resulting in reduced efficacy or withdrawal syndrome in depen…
Codeine Sulfate + Rifampin— CYP3A4 inducer that decreases codeine and morphine levels, resulting in reduced efficacy or withdrawal syndrome in depen…
Codeine Sulfate + Ritonavir— Protease inhibitor and CYP3A4 inhibitor that increases codeine and morphine levels, potentially causing fatal respirator…

Minor (2)

Codeine Sulfate + Hydrocodone— If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as …
Codeine Sulfate + Oxycodone— If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as …

Codeine Sulfate + Carbamazepine⚠️Major

CYP3A4 inducer that decreases codeine and morphine levels, resulting in reduced efficacy or withdrawal syndrome in dependent patients.

Codeine Sulfate + Erythromycin⚠️Major

CYP3A4 inhibitor that increases codeine plasma concentrations and morphine levels, potentially causing fatal respiratory depression.

Codeine Sulfate + Ketoconazole⚠️Major

Azole antifungal CYP3A4 inhibitor that increases codeine and morphine levels, potentially causing fatal respiratory depression.

Codeine Sulfate + Phenytoin⚠️Major

CYP3A4 inducer that decreases codeine and morphine levels, resulting in reduced efficacy or withdrawal syndrome in dependent patients.

Codeine Sulfate + Rifampin⚠️Major

CYP3A4 inducer that decreases codeine and morphine levels, resulting in reduced efficacy or withdrawal syndrome in dependent patients.

Codeine Sulfate + Ritonavir⚠️Major

Protease inhibitor and CYP3A4 inhibitor that increases codeine and morphine levels, potentially causing fatal respiratory depression.

Codeine Sulfate + Hydrocodone🟢Minor

If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids (such as oxycodone, hydrocodone, oxymorphone, hydrocodone, or buprenorphine) to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression.

Codeine Sulfate + Oxycodone🟢Minor

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.