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Cimetidine Hydrochloride

Also known as: Cimetidine Hydrochloride

Route: Oral

Check Cimetidine Hydrochloride Interactions →

10 interactions on record

Cimetidine Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lidocaine, Phenytoin, Theophylline. Patients taking Cimetidine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Major: 4
Moderate: 6

Major (4)

Cimetidine Hydrochloride + Lidocaine— Cimetidine reduces hepatic metabolism of lidocaine, increasing blood levels with reported adverse clinical effects.
Cimetidine Hydrochloride + Phenytoin— Cimetidine reduces hepatic metabolism of phenytoin, delaying elimination and increasing blood levels with reported adver…
Cimetidine Hydrochloride + Theophylline— Cimetidine reduces hepatic metabolism of theophylline, increasing blood levels. Adverse clinical effects reported; monit…
Cimetidine Hydrochloride + Warfarin— Cimetidine reduces hepatic metabolism of warfarin, increasing blood levels and delaying elimination. Clinically signific…

Moderate (6)

Cimetidine Hydrochloride + Chlordiazepoxide— Cimetidine reduces hepatic metabolism of chlordiazepoxide, delaying elimination and increasing blood levels.
Cimetidine Hydrochloride + Diazepam— Cimetidine reduces hepatic metabolism of diazepam, delaying elimination and increasing blood levels.
Cimetidine Hydrochloride + Ketoconazole— Cimetidine-induced pH alteration may affect ketoconazole absorption. Ketoconazole should be given at least 2 hours befor…
Cimetidine Hydrochloride + Metronidazole— Cimetidine reduces hepatic metabolism of metronidazole, delaying elimination and increasing blood levels.
Cimetidine Hydrochloride + Nifedipine— Cimetidine reduces hepatic metabolism of nifedipine, delaying elimination and increasing blood levels.
Cimetidine Hydrochloride + Propranolol— Cimetidine reduces hepatic metabolism of propranolol, delaying elimination and increasing blood levels.

Cimetidine Hydrochloride + Lidocaine⚠️Major

Cimetidine reduces hepatic metabolism of lidocaine, increasing blood levels with reported adverse clinical effects.

Cimetidine Hydrochloride + Phenytoin⚠️Major

Cimetidine reduces hepatic metabolism of phenytoin, delaying elimination and increasing blood levels with reported adverse clinical effects.

Cimetidine Hydrochloride + Theophylline⚠️Major

Cimetidine reduces hepatic metabolism of theophylline, increasing blood levels. Adverse clinical effects reported; monitoring recommended regardless of cimetidine dosing.

Cimetidine Hydrochloride + Warfarin⚠️Major

Cimetidine reduces hepatic metabolism of warfarin, increasing blood levels and delaying elimination. Clinically significant effects reported; close monitoring of prothrombin time and dose adjustment recommended.

Cimetidine Hydrochloride + Chlordiazepoxide🟡Moderate

Cimetidine reduces hepatic metabolism of chlordiazepoxide, delaying elimination and increasing blood levels.

Cimetidine Hydrochloride + Diazepam🟡Moderate

Cimetidine reduces hepatic metabolism of diazepam, delaying elimination and increasing blood levels.

Cimetidine Hydrochloride + Ketoconazole🟡Moderate

Cimetidine-induced pH alteration may affect ketoconazole absorption. Ketoconazole should be given at least 2 hours before cimetidine.

Cimetidine Hydrochloride + Metronidazole🟡Moderate

Cimetidine reduces hepatic metabolism of metronidazole, delaying elimination and increasing blood levels.

Cimetidine Hydrochloride + Nifedipine🟡Moderate

Cimetidine reduces hepatic metabolism of nifedipine, delaying elimination and increasing blood levels.

Cimetidine Hydrochloride + Propranolol🟡Moderate

Cimetidine reduces hepatic metabolism of propranolol, delaying elimination and increasing blood levels.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.