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Sodium Iodide I 131

Also known as: Sodium Iodide I 131 Diagnostic

Route: Oral

Check Sodium Iodide I 131 Interactions →

13 interactions on record

Sodium Iodide I 131 has 13 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Bone Marrow Depressants, Amiodarone, Carbimazole. Patients taking Sodium Iodide I 131 should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 13
Major: 1
Moderate: 11

Major (1)

Sodium Iodide I 131 + Bone Marrow Depressants— Concomitant use may enhance depression of the hematopoietic system caused by large doses of sodium iodide I 131.

Moderate (11)

Sodium Iodide I 131 + Amiodarone— Drug that interferes with accumulation of radioiodide by the thyroid. Discontinue 6 months before procedure.
Sodium Iodide I 131 + Carbimazole— Thionamide medication that interferes with accumulation of radioiodide by the thyroid. Discontinue 3 days before procedu…
Sodium Iodide I 131 + Levothyroxine— Natural or synthetic thyroid hormone that interferes with radioiodide accumulation. Discontinue 4 weeks before procedure…
Sodium Iodide I 131 + Lugol Solution— Iodide-containing agent that interferes with radioiodide accumulation. Discontinue 3 weeks before procedure.
Sodium Iodide I 131 + Methimazole— Thionamide medication that interferes with accumulation of radioiodide by the thyroid. Discontinue 3 days before procedu…
Sodium Iodide I 131 + Oral Cholecystographic Contrast Agents— Radiographic contrast agent that interferes with radioiodide accumulation. Discontinue 6 months before procedure.
Sodium Iodide I 131 + Potassium Iodide— Interferes with accumulation of radioiodide by the thyroid; discontinue 3 weeks before procedure.
Sodium Iodide I 131 + Propylthiouracil— Thionamide medication that interferes with accumulation of radioiodide by the thyroid. Discontinue 3 days before procedu…
Sodium Iodide I 131 + Saturated Solution Of Potassium Iodide— Iodide-containing agent that interferes with radioiodide accumulation. Discontinue 3 weeks before procedure.
Sodium Iodide I 131 + Triiodothyronine— Natural or synthetic thyroid hormone that interferes with radioiodide accumulation. Discontinue 2 weeks before procedure…
Sodium Iodide I 131 + Water Soluble Intravenous Radiographic Contrast Agents— Radiographic contrast agent that interferes with radioiodide accumulation. Discontinue 2 months before procedure.

Sodium Iodide I 131 + Bone Marrow Depressants⚠️Major

Concomitant use may enhance depression of the hematopoietic system caused by large doses of sodium iodide I 131.

Sodium Iodide I 131 + Amiodarone🟡Moderate

Drug that interferes with accumulation of radioiodide by the thyroid. Discontinue 6 months before procedure.

Sodium Iodide I 131 + Carbimazole🟡Moderate

Thionamide medication that interferes with accumulation of radioiodide by the thyroid. Discontinue 3 days before procedure.

Sodium Iodide I 131 + Levothyroxine🟡Moderate

Natural or synthetic thyroid hormone that interferes with radioiodide accumulation. Discontinue 4 weeks before procedure.

Sodium Iodide I 131 + Lugol Solution🟡Moderate

Iodide-containing agent that interferes with radioiodide accumulation. Discontinue 3 weeks before procedure.

Sodium Iodide I 131 + Methimazole🟡Moderate

Thionamide medication that interferes with accumulation of radioiodide by the thyroid. Discontinue 3 days before procedure.

Sodium Iodide I 131 + Oral Cholecystographic Contrast Agents🟡Moderate

Radiographic contrast agent that interferes with radioiodide accumulation. Discontinue 6 months before procedure.

Sodium Iodide I 131 + Potassium Iodide🟡Moderate

Interferes with accumulation of radioiodide by the thyroid; discontinue 3 weeks before procedure.

Sodium Iodide I 131 + Propylthiouracil🟡Moderate

Thionamide medication that interferes with accumulation of radioiodide by the thyroid. Discontinue 3 days before procedure.

Sodium Iodide I 131 + Saturated Solution Of Potassium Iodide🟡Moderate

Iodide-containing agent that interferes with radioiodide accumulation. Discontinue 3 weeks before procedure.

Sodium Iodide I 131 + Triiodothyronine🟡Moderate

Natural or synthetic thyroid hormone that interferes with radioiodide accumulation. Discontinue 2 weeks before procedure.

Sodium Iodide I 131 + Water Soluble Intravenous Radiographic Contrast Agents🟡Moderate

Radiographic contrast agent that interferes with radioiodide accumulation. Discontinue 2 months before procedure.

Sodium Iodide I 131 + Ethionamideℹ️Unknown

Table 4 Pharmaceuticals / OTCs / Agents Blocking Radioiodine Uptake Type of Medication Recommended time of withdrawal Thionamide medications (e.g., propylthiouracil, methimazole, carbimazole) 3 days Multivitamins containing iodide 10 days Natural or synthetic thyroid hormones triiodothyronine thyroxine 2 weeks 4 weeks Iodide-containing foods: iodized salt, dairy products, egg yolks, seafood, turkey and liver 2 weeks Kelp, agar, carrageenan, Lugol solution 3 weeks Saturated solution of potassium iodide 3 weeks Topical iodide (e.g., surgical skin preparation) 3 weeks Intravenous radiographic contrast agents Water soluble Lipophilic 2 months 6 months Amiodarone 6 months Many pharmacologic agents are known to interact with radioiodide.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.