Salicylic Acid has 18 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Heparin, Methotrexate, Oral Anticoagulants. Patients taking Salicylic Acid should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Major
- 3
- Moderate
- 15
Major (3)
- Salicylic Acid + Heparin— Salicylate decreases platelet adhesiveness and interferes with hemostasis in heparin-treated patients.
- Salicylic Acid + Methotrexate— Salicylate decreases tubular reabsorption of methotrexate, which can result in clinical toxicity.
- Salicylic Acid + Oral Anticoagulants— Salicylate competes for serum albumin binding, increasing bleeding risk in patients on oral anticoagulants.
Moderate (15)
- Salicylic Acid + Acidifying Agents— Acidifying agents increase plasma salicylate levels by altering renal tubular reabsorption.
- Salicylic Acid + Adapalene— Particular caution advised when using salicylic acid preparations with adapalene cream due to potential for increased lo…
- Salicylic Acid + Alkanizing Agents— Alkanizing agents decrease plasma salicylate levels by altering renal tubular reabsorption.
- Salicylic Acid + Ammonium Sulfate— Ammonium sulfate increases plasma salicylate levels.
- Salicylic Acid + Corticosteroids— Corticosteroids decrease plasma salicylate levels; tapering doses may promote salicylism.
- Salicylic Acid + Heparin Sodium— Interferes with platelet aggregation and may induce bleeding. Use with caution; dose reduction of antiplatelet agent or …
- Salicylic Acid + Norelgestromin And Ethinyl Estradiol— CHCs have been shown to decrease plasma concentrations of salicylic acid.
- Salicylic Acid + Norethindrone Acetate, Ethinyl Estradiol And Ferrous Fumarate— Oral contraceptives may induce conjugation of salicylic acid, increasing its clearance.
- Salicylic Acid + Norethindrone Acetate/Ethinyl Estradiol— Oral contraceptives may induce conjugation of salicylic acid, increasing its clearance and decreasing plasma concentrati…
- Salicylic Acid + Phenylbutazone— Salicylate inhibits the uricosuric effect of phenylbutazone.
- Salicylic Acid + Probenecid— Salicylate inhibits the uricosuric effect of probenecid.
- Salicylic Acid + Pyrazinamide— Salicylate inhibits pyrazinamide-induced hyperuricemia.
- Salicylic Acid + Sulfinpyrazone— Salicylate inhibits the uricosuric effect of sulfinpyrazone.
- Salicylic Acid + Tolbutamide— Salicylate competes with tolbutamide for serum albumin binding, potentiating hypoglycemia.
- Salicylic Acid + Tretinoin— Particular caution should be exercised when using preparations containing salicylic acid with tretinoin due to possible …