Levoleucovorin Calcium has 6 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fluorouracil, Sulfamethoxazole And Trimethoprim, Phenobarbital. Patients taking Levoleucovorin Calcium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Major
- 2
- Moderate
- 3
Major (2)
- Levoleucovorin Calcium + Fluorouracil— Levoleucovorin increases the toxicity of fluorouracil. Do not initiate/continue therapy in patients with gastrointestina…
- Levoleucovorin Calcium + Sulfamethoxazole And Trimethoprim— Concomitant use for acute treatment of Pneumocystis jiroveci pneumonia in HIV patients was associated with increased tre…
Moderate (3)
- Levoleucovorin Calcium + Phenobarbital— Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible childr…
- Levoleucovorin Calcium + Phenytoin— Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible childr…
- Levoleucovorin Calcium + Primidone— Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible childr…